An internal standard for the quantification of 11-dehydro thromboxane B2
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Unlabeled Version(s)
1950011-dehydro Thromboxane B2
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11-dehydro Thromboxane B2-d4

Item No. 319500

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
9α,15S-dihydroxy-11-oxothromba-5Z,13E-dien-1-oic-3,3,4,4-d4 acid
CAS Number
1240398-15-5
Synonyms
  • 11-dehydro TXB2-d4
  • 11-keto TXB2-d4
Molecular Formula
C20H28D4O6
Formula Weight
372.5
Purity
≥99% deuterated forms (d1-d4)
Formulation
A 100 µg/ml solution in methyl acetate
Solubility(Learn about Variance in Solubility)
DMF: >50 mg/mlDMSO: >25 mg/mlEthanol: >100 mg/mlPBS (pH 7.2): >100 µg/ml
SMILES
O[C@@H]1[C@H](C/C=C\C([2H])([2H])C([2H])([2H])CC(O)=O)[C@@H](/C=C/[C@H](O)CCCCC)OC(C1)=O
InChi Code
InChI=1S/C20H32O6/c1-2-3-6-9-15(21)12-13-18-16(17(22)14-20(25)26-18)10-7-4-5-8-11-19(23)24/h4,7,12-13,15-18,21-22H,2-3,5-6,8-11,14H2,1H3,(H,23,24)/b7-4-,13-12+/t15-,16-,17-,18+/m0/s1/i5D2,8D2
InChi Key
KJYIVXDPWBUJBQ-DDHOZZTNSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    25 µg

    $209

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    50 µg

    $397

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    100 µg

    $752

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    500 µg

    $3,135

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    Product Description

    11-dehydro Thromboxane B2-d4 (TXB2-d4) is intended for use as an internal standard for the quantification of 11-dehydro TXB2 (Item No. 19500) by stable isotope dilution MS. TXB2 is released in substantial quantities from aggregating platelets and metabolized during circulation to 11-dehydro TXB2 and 2,3-dinor TXB2.1 11-dehydro TXB2 is one of the main plasma metabolites of TXB2 and can be used as a marker for in vivo TXA2 synthesis.1,2,3,4 The mean plasma level in human males is 0.9-4.3 pg/ml and the half life is 45-60 minutes.2,3,4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Ciabattoni, G., Pugliese, F., Davi, G., et al. Fractional conversion of thromboxane B2 to urinary 11-dehydrothromboxane B2 in man. Biochim. Biophys. Acta 992(1), 66-70 (1989).

    2. Fitzgerald, G.A., Lawson, J., Blair, I.A., et al. Analysis of urinary metabolites of thromboxane and prostacyclin by negative-ion chemical-ionization gas chromatography/mass spectrometry. Adv. Prostaglandin Thromboxane Leukot. Res. 15, 87-90 (1985).

    3. Takasaki, W., Nakagawa, A., Tanaka, Y., et al. Enzyme immunoassay of human plasma 11-dehydrothromboxane B2. Thromb. Res. 63(3), 331-341 (1991).

    4. Catella, F., Healy, D., Lawson, J.A., et al. 11-dehydro Thromboxane B2: A quantitative index of thromboxane A2 formation in the human circulation. Proc. Natl. Acad. Sci. USA 83(16), 5861-5865 (1986).

    Product Citations

    Sasaki, A., Fukuda, H., Shiida, N., et al. Determination of ω-6 and ω-3 PUFA metabolites in human urine samples using UPLC/MS/MS. Anal. Bioanal. Chem. 407(6), 1625-1639 (2015).