An internal standard for the quantification of 12-epi leukotriene B4
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Unlabeled Version(s)
2013512-epi Leukotriene B4
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12-epi Leukotriene B4-d4

Item No. 320135

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
5S,12S-dihydroxy-6Z,8E,10E,14Z-eicosatetraenoic-6,7,14,15-d4 acid
Synonyms
  • 12-epi LTB4-d4
Molecular Formula
C20H28D4O4
Formula Weight
340.5
Purity
≥99% deuterated forms (d1-d4)
Formulation
A 100 µg/ml solution in acetonitrile
Solubility(Learn about Variance in Solubility)
DMF: MiscibleDMSO: MiscibleEthanol: MisciblePBS (pH 7.2): 1 mg/ml
λmax
270 nm
SMILES
CCCCC/C([2H])=C([2H])\C[C@H](O)/C=C/C=C/C([2H])=C([2H])\[C@@H](O)CCCC(O)=O
InChi Code
InChI=1S/C20H32O4/c1-2-3-4-5-6-9-13-18(21)14-10-7-8-11-15-19(22)16-12-17-20(23)24/h6-11,14-15,18-19,21-22H,2-5,12-13,16-17H2,1H3,(H,23,24)/b8-7+,9-6-,14-10+,15-11-/t18-,19+/m0/s1/i6D,9D,11D,15D
InChi Key
VNYSSYRCGWBHLG-WQNOCAEQSA-N
Shipping & Storage Information
Storage
-80°C
Shipping
Dry ice in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    25 µg

    $356

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    50 µg

    $676

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    100 µg

    $1,274

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    Product Description

    12-epi Leukotriene B4-d4 (12-epi LTB4-d4) contains four deuterium atoms at the 6, 7, 14, and 15 positions. It is intended for use as an internal standard for the quantification of 12-epi LTB4 by GC- or LC-mass spectrometry. 12-epi LTB4 is the “unnatural” 12(S) epimer of LTB4. 12-epi LTB4 does not appear in any measurable amount in the LTB4 isomers produced by non-enzymatic hydrolysis of LTA4.1 There are no published reports on the biological activity of 12-epi LTB4.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Sala, A., Bolla, M., Zarini, S., et al. Release of leukotriene A4 versus leukotriene B4 from human polymorphonuclear leukocytes. The Journal of Biological Chemisty 271, 17944-17948 (1996).

    Product Citations

    Sorgi, C.A., Peti, A.P.F., Petta, T., et al. Comprehensive high-resolution multiple-reaction monitoring mass spectrometry for targeted eicosanoid assays. Sci. Data 5, 180167 (2018).