Active • Host: HEK293 cells • AA: 22-152 • MW: 14.1 kDa
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LAIR-2 (human, recombinant)

Item No. 32019

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Synonyms
  • CD306
  • Leukocyte-associated Immunoglobulin-like Receptor 2
Purity
≥93% estimated by SDS-PAGE
Endotoxin Testing
<1.0 EU/μg, determined by the LAL endotoxin assay
Source
Active recombinant human LAIR-2 expressed in HEK293 cells
Amino Acids
22-152
MW
14.1 kDa
Formulation (Request formulation change)
Lyophilized from sterile 50 mM Tris with 0.7 M sodium chloride, pH 8.0
Shipping & Storage Information
Storage
-80°C
Shipping
Dry ice in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

    100 µg

    $361

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    1 mg

    $2,345

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    Cayman Chemical
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    Product Description

    Leukocyte-associated immunoglobulin-like receptor 2 (LAIR-2) is a soluble homolog of the membrane-bound inhibitory immune receptor LAIR-1.1 LAIR-2, which is comprised of a single immunoglobulin-like domain, binds to collagen and inhibits the LAIR-1/collagen interaction and subsequent activation of immunocytes.1,2 It is produced by human peripheral blood mononuclear cells (PBMCs), monocytic and T cell lines, and activated CD4+ T cells.2,3 LAIR-2 fused to the Fc region of human IgG1 inhibits collagen-induced platelet aggregation, adhesion of platelets to collagen-coated coverslips, and binding of collagen to von Willebrand factor (VWF) and glycoprotein VI (GpVI).4 Elevated levels of LAIR-2 have been found in the urine of pregnant women, the synovial fluid of patients with rheumatoid arthritis, and sera from patients with autoimmune thyroid diseases.2,1 Cayman's LAIR-2 (human, recombinant) protein can be used for binding assay applications. This protein consists of 131 amino acids, has a calculated molecular weight of 14.1 kDa, and a predicted N-terminus of Gln22 after signal peptide cleavage. By SDS-PAGE, under reducing conditions, the apparent molecular mass of the protein is 22 kDa due to glycosylation.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Simone, R., Pesce, G., Antola, P., et al. Serum LAIR-2 is increased in autoimmune thyroid diseases. PLoS One 8(5), e63282 (2013).

    2. Lebbink, R.J., van den Berg, M.C.W., de Ruiter, T., et al. The soluble leukocyte-associated Ig-like receptor (LAIR)-2 antagonizes the collagen/LAIR-1 inhibitory immune interaction. J. Immunol. 180(3), 1662-1669 (2008).

    3. Olde Nordkamp, M.J.M., van Roon, J.A.G., Douwes, M., et al. Enhanced secretion of leukocyte-associated immunoglobulin-like receptor 2 (LAIR-2) and soluble LAIR-1 in rheumatoid arthritis: LAIR-2 is a more efficient antagonist of the LAIR-1-collagen inhibitory interaction than is soluble LAIR-1. Arthritis Rheum. 63(12), 3749-3757 (2011).

    4. Lenting, P.J., Westerlaken, G.H.A., Denis, C.V., et al. Efficient inhibition of collagen-induced platelet activation and adhesion by LAIR-2, a soluble Ig-like receptor family member. PLoS One 5(8), e12174 (2010).