SOD2/Mn-SOD (human, recombinant)

Superoxide dismutase 2 (SOD2)/manganese SOD (Mn-SOD) is an antioxidant enzyme that protects cells from oxidative stress by scavenging superoxide anions.¹ It exists as a homotetramer where each monomer is composed of an N-terminal α-hairpin domain and a C-terminal α/β domain that contain Mn-binding catalytic active sites.^1,2 SOD2 is expressed in the mitochondria and is localized to the mitochondrial matrix where it catalyzes the dismutation of superoxide to hydrogen peroxide and oxygen by alternating reduction and reoxidation of Mn at the enzyme active site.¹ Genetic deletion of Sod2 in mice induces metabolic acidosis and lipid accumulation in the liver and skeletal muscle, and is perinatal lethal.³ Transgenic SOD2 overexpression reduces superoxide levels in the hippocampal CA1 region and extends the lifespan of aged mice.⁴ SOD2 expression is reduced in tumors from patients with hepatocellular carcinoma (HCC) and this decrease is associated with increased tumor number, metastasis, and reduced survival.⁵ SOD2 SNPs have been found in patients with non-Hodgkin's lymphoma, lung cancer, or colorectal cancer.⁶ Cayman's SOD2/Mn-SOD (human, recombinant) protein consists of 199 amino acids and has a calculated molecular weight of 22.3 kDa. By SDS-PAGE, under reducing conditions, the apparent molecular mass of the protein is approximately 25 kDa.

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1. Fukai, T., and Ushio-Fukai, M. Superoxide dismutases: Role in redox signaling, vascular function, and diseases. Antioxid. Redox Signal. 15(6), 1583-1606 (2011).

2. Perry, J.J.P., Shin, D.S., Getzoff, E.D., et al. The structural biochemistry of the superoxide dismutases. Biochim. Biophys. Acta 1804(2), 245-262 (2010).

3. Li, Y., Huang, T.T., Carlson, E.J., et al. Dilated cardiomyopathy and neonatal lethality in mutant mice lacking manganese superoxide dismutase. Nat. Genet. 11(4), 376-381 (1995).

4. Hu, D., Cao, P., Thiels, E., et al. Hippocampal long-term potentiation, memory, and longevity in mice that overexpress mitochondrial superoxide dismutase. Neurobiol. Learn. Mem. 87(3), 372-384 (2007).

5. Wang, R., Yin, C., Li, X.-X., et al. Reduced SOD2 expression is associated with mortality of hepatocellular carcinoma patients in a mutant p53-dependent manner. Aging (Albany NY) 8(6), 1184-1200 (2016).

6. Kang, S.W. Superoxide dismutase 2 gene and cancer risk: Evidence from an updated meta-analysis. Int. J. Clin. Exp. Med. 8(9), 14647-14655 (2015).