Host: E. coli • AA: 2-312 (full length) • Tag: N-terminal His • MW: 35 kDa
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AIMP1 (human, recombinant)

Item No. 32058

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Synonyms
  • Aminoacyl tRNA Synthase Complex-interacting Multifunctional Protein 1
  • EMAP-2
  • Endothelial Monocyte-activating Polypeptide 2
  • Multisynthase Complex Auxiliary Component p43
  • SCYE1
  • Small Inducible Cytokine Subfamily E Member 1
Purity
≥95% estimated by SDS-PAGE
Source
Recombinant human N-terminal His-tagged AIMP1 expressed in E. coli
Amino Acids
2-312 (full length)
MW
35 kDa
Formulation (Request formulation change)
Lyophilized from sterile PBS, pH 7.4
UniProt Accession №
Q12904
Shipping & Storage Information
Storage
-80°C
Shipping
Dry ice in continental US; may vary elsewhere
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    100 µg

    $361

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    1 mg

    $2,164

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    Cayman Chemical
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    Product Description

    Aminoacyl tRNA synthase complex-interacting multifunctional protein 1 (AIMP1), also known as p43, is a component of the multi-aminoacyl-tRNA synthetase complex and also functions as a cytokine.1 Intracellular AIMP1 interacts with and stabilizes arginyl-tRNA synthetase, as well as negatively regulates TGF-β signaling by binding to and stabilizing Smurf2.2 AIMP1 can also be secreted from cells in response to stimuli including hypoxia, heat shock, and TNF-α, and secreted AIMP1 has a variety of roles in the regulation of angiogenesis, fibroblast proliferation, and glucose homeostasis.1,3,4 It also has pro-inflammatory activity and activates monocytes/macrophages, leading to the secretion of TNF-α, IL-8, and chemokine (C-C motif) ligand 2 (CCL2).4 Peripheral blood and synovial fluid levels of AIMP1 are elevated in patients with rheumatoid arthritis compared with peripheral blood isolated from healthy patients, and administration of the chimeric AIMP1 neutralizing antibody atliximab attenuates disease severity in a mouse model of collagen-induced arthritis.4 Intravenous administration of recombinant AIMP1 reduces tumor growth in an MKN45 stomach cancer mouse xenograft model.3 Cayman’s AIMP1 (human, recombinant) protein consists of 318 amino acids and has a calculated molecular weight of 35 kDa.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Park, S.G., Kang, Y.S., Kim, J.Y., et al. Hormonal activity of AIMP1/p43 for glucose homeostasis. Proc. Natl. Acad. Sci. USA 103(40), 14913-14918 (2006).

    2. Lee, Y.S., Han, J.M., Son, S.H., et al. AIMP1/p43 downregulates TGF-β signaling via stabilization of smurf2. Biochem. Biophys. Res. Commun. 371(3), 395-400 (2008).

    3. Han, J.M., Myung, H., and Kim, S. Antitumor activity and pharmacokinetic properties of ARS-interacting multi-functional protein 1 (AIMP1/p43). Cancer Lett. 287(2), 157-164 (2010).

    4. Hong, S.H., Cho, J.G., Yoon, K.J., et al. The antibody atliximab attenuates collagen-induced arthritis by neutralizing AIMP1, an inflammatory cytokine that enhances osteoclastogenesis. Biomaterials 44, 45-54 (2015).