Host: E. coli • Tag: N-terminal His • AA: 22-89 • MW: 10 kDa
Technical Support & Resources

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

CXCL12α (human, recombinant)

Item No. 32093

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Synonyms
  • Chemokine (C-X-C motif) Ligand 12
  • Intercrine Reduced in Hepatomas
  • Pre-B Cell Growth-stimulating Factor
  • SDF-1
  • Stromal Cell-derived Factor 1
Purity
≥90% estimated by SDS-PAGE
Source
Recombinant human N-terminal His-tagged CXCL12α expressed in E. coli
Amino Acids
22-89
MW
10 kDa
Formulation (Request formulation change)
Lyophilized from sterile PBS, pH 7.4
UniProt Accession №
P48061-2
Shipping & Storage Information
Storage
-80°C
Shipping
Dry ice in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    50 µg

    $240

    Add

    500 µg

    $1,558

    Add
    Product Description

    Chemokine (C-X-C motif) ligand 12 (CXCL12) is a homeostatic chemokine and member of the CXC chemokine subfamily.1 Alternative splicing of CXCL12 produces six isoforms that exhibit isoform-specific tissue distribution.2 CXCL12α is ubiquitously expressed and is composed of an N-terminal receptor binding domain, a glycosaminoglycan-binding domain, and a C-terminal domain.1,2 CXCL12α binds to atypical chemokine receptor 3 (ACKR3) and chemokine (C-X-C motif) receptor 4 (CXCR4) to induced β-arrestin and G protein-coupled receptor signaling, respectively.1 It enhances hematopoietic progenitor cell survival and chemotaxis.3 CXCL12α promotes axonal elongation of primary spinal cord motor neurons and administration of an anti-Cxcl12α antibody delays neuromuscular nerve junction regeneration in a mouse model of α-latrotoxin-induced neuromuscular degeneration.4 Cayman's CXCL12α (human, recombinant) protein consists of 84 amino acids and has a calculated molecular weight of 10 kDa.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Janssens, R., Struyf, S., and Proost, P. The unique structural and functional features of CXCL12. Cell. Mol. Immunol. 15(4), 299-311 (2018).

    2. Yu, L., Cecil, J., Peng, S.-B., et al. Identification and expression of novel isoforms of human stromal cell-derived factor 1. Gene 374, 174-179 (2006).

    3. Altenburg, J.D., Broxmeyer, H.E., Jin, Q., et al. A naturally occurring splice variant of CXCL12/stromal cell-derived factor 1 is a potent human immunodeficiency virus type 1 inhibitor with weak chemotaxis and cell survival activities. J. Virol. 81(15), 8140-8148 (2007).

    4. Negro, S., Lessi, F., Duregotti, E., et al. CXCL12α/SDF-1 from perisynaptic Schwann cells promotes regeneration of injured motor axon terminals. EMBO Mol. Med. 9(8), 1000-1010 (2017).