For immunochemical detection of IgD
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IgD (human) Rabbit Monoclonal Antibody (Clone RM123)

Item No. 32117

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Synonyms
  • Immunoglobulin D
Immunogen
Human IgD
Clone Designation
RM123
Formulation (Request formulation change)
100 µg of protein A-affinity purified monoclonal antibody
Storage Buffer
PBS with 50% glycerol, 1% BSA, and 0.09% sodium azide
Host
Rabbit
Isotype
IgG
Applications
ELISA
Cross Reactivity
(+) IgD(-) Human IgG(-) Human IgM(-) Human IGA(-) Human IgE
Species Reactivity
(+) Human
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

    100 µg

    $411

    Add
    Cayman Chemical
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    Product Description

    Immunoglobulin D (IgD) is a member of the immunoglobulin superfamily of glycoproteins that functions as a B cell antigen receptor (BCR) and has roles in adaptive immunity.1 Human IgD is composed of two Igδ heavy chains of approximately 50 kDa each and two Igĸ or Igλ light chains of approximately 25 kDa each.2,3 It is expressed on the surface of antigen-naïve mature B cells, which are found in germinal centers and peripheral blood, as well as certain subsets of circulating memory B cells.1,4 IgD levels increase during B cell maturation and are regulated by alternative splicing of an mRNA transcript that is common to the µ and δ heavy chains of IgM and IgD, respectively.1,5 Upon antigen activation, IgD can undergo class switch recombination to the immunoglobulin isotypes IgA, IgE, or IgG, each of which has a distinct effector function.6 IgD can also be produced from IgM by class switch recombination, leading to the generation of IgD-secreting plasma cells that have roles in mucosal immunity.7 IgD binds to basophil and mast cell lines, as well as the respiratory pathogens M. catarrhalis and H. influenzae, in vitro.8 Serum IgD levels are increased in patients with a variety of conditions, including leprosy, tuberculosis, malaria, or Hodgkin's lymphoma and is a hallmark of hyperimmunoglobulinemia D syndrome (HIDS), an autoinflammatory condition characterized by febrile episodes.9 Cayman's IgD (human) Rabbit Monoclonal Antibody (Clone RM123) can be used for ELISA.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Gutzeit, C., Chen, K., and Cerutti, A. The enigmatic function of IgD: Some answers at last. Eur. J. Immunol. 48(7), 1101-1113 (2018).

    2. Preud'homme, J.-L., Petit, I., Barra, A., et al. Structural and functional properties of membrane and secreted IgD. Mol. Immunol. 37(15), 871-887 (2000).

    3. Schroeder, H.W., Jr., and Cavicini, L. Structure and function of immunoglobulins. J. Allergy Clin. Immunol. 125(2 Suppl. 2), S41-S52 (2010).

    4. Seifert, M., and Küppers, R. Human memory B cells. Leukemia 30(12), 2283-2292 (2016).

    5. Geisberger, R., Lamers, M., and Achatz, G. The riddle of the dual expression of IgM and IgD. Immunology 118(4), 429-437 (2006).

    6. Stavnezer, J., and Schrader, C.E. IgH chain class switch recombination: mechanism and regulation. J. Immunol. 193(11), 5370-5378 (2014).

    7. Chen, K., and Cerutti, A. The function and regulation of immunoglobulin D. Curr. Opin. Immunol. 23(3), 345-352 (2011).

    8. Chen, K., Xu, W., Wilson, M., et al. Immunoglobulin D enhances immune surveillance by activating antimicrobial, proinflammatory and B cell–stimulating programs in basophils. Nat. Immunol. 10(8), 889-898 (2009).

    9. Vladutiu, A.O. Immunoglobulin D: Properties, measurement, and clinical relevance. Clin. Diagn. Lab Immunol. 7(2), 131-140 (2000).