For immunochemical detection of α-tubulin
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α-Tubulin Monoclonal Antibody (RM113)

Item No. 32126

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Synonyms
  • α-Tubulin Chain
Immunogen
Peptide from the C-terminal region of α-tubulin
Clone Designation
RM113
MW
50 kDa
Formulation (Request formulation change)
100 µl of protein A-affinity purified monoclonal antibody
Storage Buffer
PBS with 50% glycerol, 1% BSA, and 0.09% sodium azide
Host
Rabbit
Applications
ICC, WB
Cross Reactivity
(+) α-Tubulin 1A chain(+) α-Tubulin 1B chain
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

    100 µl

    $411

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    Product Description

    α-Tubulin is a cytoskeletal protein and constituent of microtubules, a cytoskeletal assembly that has roles in a variety of cellular processes, including cell motility, division, differentiation, and intracellular transport.1 α-Tubulin is highly conserved in eukaryotes and expressed in a cell- and isotype-specific manner.2 There are eight human α-tubulin isotypes that consist of an N-terminal domain, which binds GTP and is required for microtubule self-assembly, and a variable C-terminal tail, which contains interaction sites for microtubule-associated proteins (MAPs) and is subject to a variety of post-translational modifications that regulate microtubule function and stability.3,4,1,5 Cayman's α-Tubulin Monoclonal Antibody (RM113) can be used for immunocytochemistry (ICC) and Western blot (WB) applications. The antibody recognizes α-tubulin at approximately 50 kDa.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Gadadhar, S., Bodakuntla, S., Natarajan, K., et al. The tubulin code at a glance. J. Cell Sci. 130(8), 1347-1353 (2017).

    2. Binarová, P., and Tuszynski, J. Tubulin: Structure, functions and roles in disease. Cells 8(10), 1294 (2019).

    3. Vemu, A., Atherton, J., Spector, J.O., et al. Tubulin isoform composition tunes microtubule dynamics. Mol. Biol. Cell 28(25), 3564-3572 (2017).

    4. Valiron, O. New insights into microtubule elongation mechanisms. Commun. Integr. Biol. 4(1), 10-13 (2011).

    5. Zhang, F., Su, B., Wang, C., et al. Posttranslational modifications of α-tubulin in Alzheimer disease. Transl. Neurodegener. 4(9), (2015).