For immunochemical detection of H3T6Ph
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Histone H3T6Ph Monoclonal Antibody (RM160)

Item No. 32166

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Synonyms
  • Histone H3 (Phospho-Thr6)
  • H3pT1
  • H3pThr1
  • Phospho-Histone H3 Threonine 6
  • Phosphorylated Histone H3 Threonine 6
Immunogen
Peptide corresponding to H3T6Ph
Clone Designation
RM160
Formulation (Request formulation change)
100 µg of protein A-affinity purified monoclonal antibody
Storage Buffer
PBS with 50% glycerol, 1% BSA, and 0.09% sodium azide
Host
Rabbit
Isotype
IgG
Applications
ELISA, multiplex-based assays, WB
Cross Reactivity
(+) H3T6Ph(-) Other phosphorylated histones
Species Reactivity
(+) Vertebrates
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

    100 µg

    $500

    Add
    Cayman Chemical
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    Product Description

    Histone H3 is a nuclear protein and a component of the nucleosome core, a basic unit of chromatin, that is essential for organizing genomic DNA in eukaryotic nuclei.1 It is a globular protein that contains an unstructured N-terminal tail that extends outside of the nucleosome core and is subject to various post-translational modifications (PTMs), including methylation, phosphorylation, acetylation, and citrullination.1,2 Phosphorylation of histone H3 at threonine 6 (H3T6Ph) is associated with transcriptional activation.3 Tumor levels of H3T6Ph are positively correlated with malignancy in patients with prostate cancer. Cayman's Histone H3T6Ph Monoclonal Antibody (RM160) can be used for ELISA, multiplex-based assay, and Western blot (WB) applications.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Hyun, K., Jeon, J., Park, K., et al. Writing, erasing and reading histone lysine methylations. Exp. Mol. Med. 49(4), e324 (2017).

    2. Sharda, A., Amnekar, R.V., Natu, A., et al. Histone posttranslational modifications: Potential role in diagnosis, prognosis, and therapeutics of cancer. Prognostic Epigenetics 15, 351-373 (2019).

    3. Metzger, E., Imhof, A., Patel, D., et al. Phosphorylation of histone H3T6 by PKCβɪ controls demethylation at histone H3K4. Nature 464(7289), 792-796 (2010).