For immunochemical detection of calponin-1
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Calponin-1 (C-Term) Rabbit Monoclonal Antibody (Clone RM262)

Item No. 32207

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Synonyms
  • CaP
Immunogen
Peptide from the C-terminal region of human calponin-1
Clone Designation
RM262
Formulation (Request formulation change)
100 µl of protein A-affinity purified monoclonal antibody
Storage Buffer
PBS with 50% glycerol, 1% BSA, and 0.09% sodium azide
Host
Rabbit
Isotype
IgG
Applications
ICC, WB
Cross Reactivity
(+) Calponin-1
Species Reactivity
(+) Human(+) Mouse
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

    100 µl

    $411

    Add
    Cayman Chemical
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    Product Description

    Calponin-1 is an actin binding protein and a component of smooth muscle cell (SMC) contractile machinery that is encoded by CNN1 in humans.1,2 It is a thin filament-associated protein expressed exclusively in SMCs that interacts with actin to inhibit the movement of actin and myosin, as well as the actin-activated MgATPase activity of phosphorylated myosin.3 High levels and low levels of calponin-1 are associated with low and high disease progression risk, respectively, in patients with ductal carcinoma in situ (DCIS).4 Downregulation of arterial Cnn1 expression promotes proliferation of vascular SMCs (VSMCs) in DOCA-salt hypertensive rats and a pig model of hypertension induced by aortic coarctation.2 Cayman's Calponin-1 (C-Term) Rabbit Monoclonal Antibody (Clone RM262) can be used for immunocytochemistry (ICC) and Western blot (WB) applications.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Winder, S.J., and Walsh, M.P. Calponin: Thin filament-linked regulation of smooth muscle contraction. Cell Signal. 5(6), 677-686 (1993).

    2. Belo, V.A., Parente, J.M., Tanus-Santos, J.E., et al. Matrix metalloproteinase (MMP)-2 decreases calponin-1 levels and contributes to arterial remodeling in early hypertension. Biochem. Pharmacol. 118, 50-58 (2016).

    3. Tang, D.-C., Kang, H.-M., Jin, J.-P., et al. Structure-function relations of smooth muscle calponin. The critical role of serine 175. The Journal of Biological Chemisty 271(15), 8605-8611 (1996).

    4. Mitchell, E., Jindal, S., Chan, T., et al. Loss of myoepithelial calponin-1 characterizes high-risk ductal carcinoma in situ cases, which are further stratified by T cell composition. Mol. Carcinog. 59(7), 701-712 (2020).