For immunochemical detection of integrin α4
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Integrin α4/CD49D (C-Term) Rabbit Monoclonal Antibody (Clone RM268)

Item No. 32218

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Synonyms
  • CD49D
  • Integrin Subunit α4
  • Very Late Activation Protein 4 Receptor, α4 subunit
  • VLA-4 subunit α
  • Integrin αIV
Immunogen
Peptide from the C-terminal region of human integrin α4
Clone Designation
RM268
Formulation (Request formulation change)
100 µl of protein A-affinity purified monoclonal antibody
Storage Buffer
PBS with 50% glycerol, 1% BSA, and 0.09% sodium azide
Host
Rabbit
Isotype
IgG
Applications
IHC, WB
Cross Reactivity
(+) Integrin α4
Species Reactivity
(+) Human
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

    100 µl

    $411

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    Product Description

    Integrins are cell adhesion receptors that mediate the attachment of cells to the extracellular matrix (ECM) and facilitate cell-cell interactions.1 The integrin family contains 18 α subunits and eight β subunits that form 24 different heterodimers grouped into familial subgroups based on subunit composition and/or their ligand binding properties. Integrin α4, also known as CD49D, is a subunit of the α4β1 and α4β7 leukocyte-specific integrins, which recognize fibronectin and vascular cell adhesion molecule 1 (VCAM-1) and have essential roles in lymphocyte migration.1,2 Knockout of Itga4, the gene encoding integrin α4, induces failure of chorioallantoic fusion and is embryonic lethal in mice.1 Cayman’s Integrin α4/CD49D (C-Term) Rabbit Monoclonal Antibody (Clone RM268) can be used for immunohistochemistry (IHC) and Western blot (WB) applications.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Barczyk, M., Carracedo, S., and Gullberg, D. Integrins. Cell Tissue Res. 339(1), 269-280 (2010).

    2. Li, H., Huang, S.-Y., Shi, F.-H., et al. α4β7 integrin inhibitors: a patent review. Expert Opin. Ther. Pat. 28(12), 903-917 (2018).