For immunochemical detection of Aurora B kinase
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Aurora B Kinase (N-Term) Rabbit Monoclonal Antibody (Clone RM278)

Item No. 32228

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Synonyms
  • Aurora Kinase B
  • Aurora- and IPL-1-like Midbody-associated Protein 1
  • AIM-1
  • Aurora-related Kinase 2
  • ARK-2
Immunogen
Peptide from the N-terminal region of human Aurora B kinase
Clone Designation
RM278
Formulation (Request formulation change)
100 µl of protein A-affinity purified monoclonal antibody.
Storage Buffer
PBS with 50% glycerol, 1% BSA, and 0.09% sodium azide
Host
Rabbit
Isotype
IgG
Applications
IHC, WB
Cross Reactivity
(+) Aurora B kinase
Species Reactivity
(+) Human
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    100 µl

    $411

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    Cayman Chemical
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    Product Description

    Aurora B kinase is a serine/threonine protein kinase involved in the regulation of mitosis.1 It is composed of an N-terminal regulatory domain containing KEN- and A-box motifs, which regulate degradation of Aurora B, and a C-terminal catalytic domain containing an activation loop and a D-box, which also regulates Aurora B degradation. Aurora B kinase is ubiquitously expressed with the highest expression at the G2/M phase of the cell cycle and the highest activity during mitosis.2 It localizes to the nucleus, where it is a component of the chromosome passenger complex (CPC).3 Aurora B kinase is involved in the modification of chromatin and centromeres by phosphorylating histone H3 and centromere protein A (CENP-A), respectively, during mitosis.1,3 It is also involved in chromatid separation, by phosphorylating mitotic centromere-associated kinesin (MCAK) to stabilize kinetochore-microtubule attachments, and in the regulation of cytokinesis.1 AURKB, the gene encoding aurora B kinase, is overexpressed in a variety of cancers and its expression levels are positively correlated with disease severity, poor prognosis, and lower overall survival.2 Cayman's Aurora B Kinase (N-Term) Rabbit Monoclonal Antibody (Clone RM278) can be used for immunohistochemistry (IHC) and Western blot (WB) applications.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Fu, J., Bian, M., Jiang, Q., et al. Roles of Aurora kinases in mitosis and tumorigenesis. Mol. Cancer Res. 5(1), 1-10 (2007).

    2. Portello, G., Passaro, C., and Chieffi, P. Aurora B: A new prognostic marker and therapeutic target in cancer. Curr. Med. Chem. 18(4), 482-496 (2011).

    3. Zhang, X. Aurora kinases. Curr. Biol. 18(4), R146-148 (2008).