Integrin β1/CD29 Rabbit Monoclonal Antibody (Clone RM285)

Integrins are cell adhesion receptors that mediate the attachment of cells to the extracellular matrix (ECM) and facilitate cell-cell interactions.¹ The integrin family contains 18 α subunits and eight β subunits that form 24 different heterodimers grouped into familial subgroups based on subunit composition and/or their ligand binding properties. Integrin β1, also known as CD29, is an integrin subunit that heterodimerizes with α integrin subunits, forming 12 different α-β integrin heterodimers that function as receptors for a variety of ECM proteins, including collagens, fibronectins, and laminins, and mediate outside-in and inside-out signaling cascades that regulate numerous cellular processes, including proliferation, adhesion, survival, migration, and organogenesis.² Integrin β1 is expressed in most tissues, with high levels found in epidermal stem cells.^3,1 Increased tumor levels of integrin β1 have been found in patients with lung or breast cancer and are associated with decreased overall survival.⁴ Cayman's Integrin β1/CD29 Rabbit Monoclonal Antibody (Clone RM285) can be used for immunohistochemistry (IHC) and Western blot (WB) applications.

WARNING This product is not for human or veterinary use.

1. Barczyk, M., Carracedo, S., and Gullberg, D. Integrins. Cell Tissue Res. 339(1), 269-280 (2010).

2. Howe, G.A., and Addison, C.L. β1 integrin: An emerging player in the modulation of tumorigenesis and response to therapy. Cell Adh. Migr. 6(2), 71-77 (2012).

3. Brakebusch, C., Hirsch, E., Potocnik, A., et al. Genetic analysis of β1 integrin function: Confirmed, new and revised roles for a crucial family of cell adhesion molecules. J. Cell Sci. 110(Pt 23), 2895-2904 (1997).

4. Sun, Q., Zhou, C., Ma, R., et al. Prognostic value of increased integrin-beta 1 expression in solid cancers: A meta-analysis. Onco Targets Ther. 11, 1787-1799 (2018).