For immunochemical detection of PSD-95
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Alternative(s)
10009506PSD95 Polyclonal Antibody
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PSD-95 (N-Term) Rabbit Monoclonal Antibody (Clone RM288)

Item No. 32240

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Synonyms
  • Postsynaptic Density Protein-95
Immunogen
Peptide from the N-terminal region of human PSD-95
Clone Designation
RM288
Formulation (Request formulation change)
100 µl of protein A-affinity purified monoclonal antibody
Storage Buffer
PBS with 50% glycerol, 1% BSA, and 0.09% sodium azide
Host
Rabbit
Isotype
IgG
Applications
IHC, WB
Cross Reactivity
(+) PSD-95
Species Reactivity
(+) Human(+) Mouse
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    100 µl

    $411

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    Product Description

    Postsynaptic density protein-95 (PSD-95) is a scaffold protein and member of the membrane-associated guanylate kinase (MAGUK) family encoded by the DLG4 gene in humans.1,2 It is composed of three N-terminal PDZ domains that facilitate protein-protein interactions and are subject to palmitoylation, which regulates its membrane localization, a Src homology domain that interacts with the tyrosine kinases Src, Lyn, and Yes, and a C-terminal catalytically inactive guanylate kinase domain.1 PSD-95 is expressed in excitatory synapses and localizes to the postsynaptic density, a network of proteins that facilitates the stabilization and trafficking of receptors and ion channels to the postsynaptic membrane.1,3 PSD-95 interacts with the transmembrane AMPA receptor-associated protein stargazin, as well as the NR2 subunit of the NMDA receptor, regulating glutamatergic signaling, synaptic plasticity, and neurodevelopment.1,4 DLG4 mutations have been found in patients with schizophrenia or autism.1 Cayman's PSD-95 (N-Term) Rabbit Monoclonal Antibody (Clone RM288) can be used for immunohistochemistry (IHC) and Western blot (WB) applications.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Coley, A.A., and Gao, W.-J. PSD95: A synaptic protein implicated in schizophrenia or autism? Prog. Neuropsychopharmacol. Biol. Psychiatry 82, 187-194 (2018).

    2. Yoo, K.-S., Lee, K., Oh, J.-Y., et al. Postsynaptic density protein 95 (PSD-95) is transported by KIF5 to dendritic regions. Mol. Brain 12(1), 97 (2019).

    3. Vyas, Y., and Montgomery, J.M. The role of postsynaptic density proteins in neural degeneration and regeneration. Neural Regen. Res. 11(6), 906-907 (2016).

    4. Keith, D., and El-Husseini, A. Excitation control: Balancing PSD-95 function at the synapse. Front. Mol. Neurosci. 1, 4 (2008).