For immunochemical detection of CD11b
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ITGAM/CD11b (C-Term) Rabbit Monoclonal Antibody (Clone RM290)

Item No. 32241

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Synonyms
  • Cell Surface Glycoprotein MAC-1 Subunit α
  • Complement Component 3 Receptor 3 Subunit
  • CR3A
  • Integrin subunit αM
  • ITGAM
  • MAC-1
Immunogen
Peptide from the C-terminal region of human CD11b
Clone Designation
RM290
Formulation (Request formulation change)
100 µl of protein A-affinity purified monoclonal antibody
Storage Buffer
PBS with 50% glycerol, 1% BSA, and 0.09% sodium azide
Host
Rabbit
Isotype
IgG
Applications
IHC and WB
Cross Reactivity
(+) CD11b
Species Reactivity
(+) Human
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    100 µl

    $411

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    Cayman Chemical
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    Product Description

    CD11b, also known as integrin αM (ITGAM), is a protein subunit of the heterodimeric leukocyte integrin αMβ2, the major integrin expressed in phagocytes with roles in host defense.1 It is composed of an ectodomain containing a β-propeller domain followed by a thigh domain and calf-1 and calf-2 domains, a transmembrane segment, and a cytoplasmic tail.1,2 CD11b is expressed as a component of αMβ2 on the surface of leukocytes, including macrophages, dendritic cells, monocytes, neutrophils, natural killer cells, and granulocytes, that binds to ICAM and VCAM to facilitate macrophage extravasation, as well as complement C3-opsonized pathogens and immune complexes to mediate their internalization and phagocytosis.1 Mutations in ITGAM are associated with susceptibility to systemic lupus erythematosus (SLE).3 Cayman’s ITGAM/CD11b (C-Term) Rabbit Monoclonal Antibody (Clone RM290) can be used for immunohistochemistry (IHC) and Western blot (WB) applications.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Bednarczyk, M., Stege, H., Grabbe, S., et al. β2 Integrins—multi-functional leukocyte receptors in health and disease. Int. J. Mol. Sci. 21(4), 1402 (2020).

    2. Adair, B.D., Xiong, J.-P., Alonso, J.L., et al. EM structure of the ectodomain of integrin CD11b/CD18 and localization of its ligand-binding site relative to the plasma membrane. PLoS One 8(2), e57951 (2013).

    3. Fagerholm, S.C., MacPherson, M., James, M.J., et al. The CD11b-integrin (ITGAM) and systemic lupus erythematosus. Lupus 22(7), 657-663 (2013).