For immunochemical detection of CD79a
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CD79a (C-Term) Rabbit Monoclonal Antibody (Clone RM297)

Item No. 32243

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Synonyms
  • B Cell Antigen Receptor Complex-associated Protein α Chain
  • Igα
  • MB-1 Membrane Glycoprotein
Immunogen
Peptide from the C-terminal region of human CD79a
Clone Designation
RM297
Formulation (Request formulation change)
100 µl of protein A-affinity purified monoclonal antibody
Storage Buffer
PBS with 50% glycerol, 1% BSA, and 0.09% sodium azide
Host
Rabbit
Isotype
IgG
Applications
IHC, WB
Cross Reactivity
(+) CD79a
Species Reactivity
(+) Human
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

    100 µl

    $411

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    Product Description

    CD79a is a member of the heterodimeric signal transduction component of the B cell receptor (BCR) complex that is encoded by CD79A/MB-1 in humans.1 It is composed of a disulfide-linked extracellular domain, a transmembrane region, and a cytoplasmic tail containing an immunoreceptor tyrosine-based activation motif that facilitates intracellular signaling.1,2 CD79a is expressed exclusively in B cells and B cell progenitors, and is commonly used as a B cell marker. It is co-expressed at the cell surface with CD79b and immunoglobulins of all isotypes as the mature BCR complex.1 Mutations in CD79A/MB-1 have been found in patients with autosomal recessive agammaglobulinemia.3 Cayman's CD79a (C-Term) Rabbit Monoclonal Antibody (Clone RM297) can be used for immunohistochemistry (IHC) and Western blot (WB) applications.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Schroeder, H.W., Jr., Imboden, J.B., and Torres, R.M. Antigen receptor genes, gene products, and co-receptors. Clinical immunology: Principles and practice 47-67 (2013).

    2. Wang, L.D., and Clark, M.R. B-cell antigen-receptor signalling in lymphocyte development. Immunology 110(4), 411-420 (2003).

    3. Khalili, A., Plebani, A., Vitali, M., et al. Autosomal recessive agammaglobulinemia: A novel non-sense mutation in CD79a. J. Clin. Immunol. 34(2), 138-141 (2014).