For immunochemical detection of S100B
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S100B (C-Term) Rabbit Monoclonal Antibody (Clone RM304)

Item No. 32249

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Synonyms
  • S100 Calcium-binding Protein B
  • S100 Protein β Chain
  • S100 Protein Subunit β
  • S100β
Immunogen
Peptide from the C-terminal region of human S100B
Clone Designation
RM304
Formulation (Request formulation change)
100 µl of protein A-affinity purified monoclonal antibody
Storage Buffer
PBS with 50% glycerol, 1% BSA, and 0.09% sodium azide
Host
Rabbit
Isotype
IgG
Applications
IHC, WB
Cross Reactivity
(+) S100B
Species Reactivity
(+) Human
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    100 µl

    $411

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    Product Description

    S100 calcium-binding protein B (S100B) is a calcium-binding protein.1 It is a homodimer, with each subunit containing two EF-hand calcium-binding domains. S100B is expressed primarily in astrocytes but also by neural progenitor cells, dendritic cells, some lymphocyte subpopulations, and maturing oligodendrocytes. SB100B has intracellular roles in calcium homeostasis, cell proliferation, energy metabolism, cytoskeletal regulation, and motility. It is also released extracellularly in response to various forms of brain injury and acts as a damage-associated molecular pattern (DAMP) through its interaction with receptor for advanced glycation end products (RAGE).1,2,3,4 Peripheral blood levels of SB100 are increased in patients with autism spectrum disorder, acute ischemic stroke, or neonatal brain injury.2,3,4 Cayman's S100B (C-Term) Rabbit Monoclonal Antibody (Clone RM304) can be used for immunohistochemistry (IHC) and Western blot (WB) applications.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Angelopoulou, E., Paudel, Y.N., and Piperi, C. Emerging role of S100B protein implication in Parkinson’s disease pathogenesis. Cell. Mol. Life Sci. 78(4), 1445-1453 (2021).

    2. Zheng, Z., Zheng, P., and Zou, X. Peripheral blood S100B levels in autism spectrum disorder: A systematic review and meta-analysis. J. Autism Dev. Disord. 51(8), 2569-2577 (2021).

    3. Onatsu, J., Vanninen, R., Jäkälä, P., et al. Tau, S100B and NSE as blood biomarkers in acute cerebrovascular events. In Vivo 34(5), 2577-2586 (2020).

    4. Metallinou, D., Karampas, G., Nyktari, G., et al. S100B as a biomarker of brain injury in premature neonates. A prospective case - control longitudinal study. Clin. Chim. Acta 510, 781-786 (2020).