Calretinin (N-Term) Rabbit Monoclonal Antibody (Clone RM324)

Calretinin is a calcium-binding protein and member of the large EF-hand protein family that is encoded by CALB2 in humans.¹ It is composed of six EF-hand domains, each of which contains two α-helices oriented perpendicular to each other around a calcium-binding domain. Calretinin is expressed in specific neuronal populations, including granule cells of the cerebellum, auditory neurons, and retinal neurons, and is localized to the cytosol where it has a role in the modulation of neuronal excitability. It is also expressed under pathological conditions, particularly in epithelial mesothelioma cells and colon adenocarcinomas. Calb2^-/- mice exhibit impaired induction of long-term potentiation following tetanic hippocampal stimulation. Levels of calretinin are increased in the dorsomedial and ventromedial hypothalamic nuclei in aged rats.² Cayman's Calretinin (N-Term) Rabbit Monoclonal Antibody (Clone RM324) can be used for immunohistochemistry (IHC) and Western blot (WB) applications.

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1. Camp, A.J., and Wijesinghe, R. Calretinin: Modulator of neuronal excitability. Int. J. Biochem. Cell Biol. 41(11), 2118-2121 (2009).

2. Vishnyakova, P.A., Moiseev, K.Y., Spirichev, A.A., et al. Expression of calbindin and calretinin in the dorsomedial and ventromedial hypothalamic nuclei during aging. Anat. Rec. (Hoboken) (2020).