For immunochemical detection of PSMA
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PSMA (C-Term) Rabbit Monoclonal Antibody (Clone RM327)

Item No. 32265

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Synonyms
  • Folate Hydrolase 1
  • FOLH1
  • GCPII
  • Glutamate Carboxypeptidase II
  • NAALADase
  • Prostate-specific Membrane Antigen
Immunogen
A peptide from the C-terminal region of human PSMA
Clone Designation
RM327
Formulation (Request formulation change)
100 µl of protein A-affinity purified monoclonal antibody
Storage Buffer
PBS, with 50% glycerol, 1% BSA, and 0.09% sodium azide
Host
Rabbit
Isotype
IgG
Applications
IHC, WB
Cross Reactivity
(+) PSMA
Species Reactivity
(+) Human
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

    100 µl

    $411

    Add
    Cayman Chemical
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    Product Description

    Prostate-specific membrane antigen (PSMA) is a type II membrane glycoprotein and a glutamate-preferring carboxypeptidase with roles in folic acid utilization and metabolism encoded by FOLH1 in humans.1,2 It is composed of a short intracellular domain, a transmembrane domain, and a large extracellular region that contains enzymatic domains.1,3 PSMA is expressed in prostate epithelial cells and is highly overexpressed in prostate carcinomas. PSMA is also expressed in the central nervous system, where it metabolizes N-acetyl-aspartyl-glutamate, and in the proximal small intestine, where it functions as a carboxypeptidase and a folate hydrolase, as well as in the neovasculature of various renal, colon, and breast carcinomas.2,4 Expression of FOLH1 increases under androgen deprivation conditions in vitro and in vivo and positively correlates with cancer aggressiveness in patients with prostate cancer.1 PSMA positron emission tomography (PET) imaging is commonly used in the diagnosis and staging of prostate cancer, as well as to assess therapeutic response.3 Cayman’s PSMA (C-Term) Rabbit Monoclonal Antibody (Clone RM327) can be used for immunohistochemistry (IHC) and Western blot (WB) applications.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Chang, S.S. Overview of prostate-specific membrane antigen. Rev. Urol. 10(Suppl. 10), S13-S18 (2004).

    2. Mannweiler, S., Amersdorfer, P., Trajanoski, S., et al. Heterogeneity of prostate-specific membrane antigen (PSMA) expression in prostate carcinoma with distant metastasis. Pathol. Oncol. Res. 15(2), 167-172 (2009).

    3. de Galiza Barbosa, F., Queiroz, M.A., Nunes, R.F., et al. Nonprostatic diseases on PSMA PET imaging: A spectrum of benign and malignant findings. Cancer Imaging 20(1), 23 (2020).

    4. Ghosh, A., and Heston, W.D.W. Tumor target prostate specific membrane antigen (PSMA) and its regulation in prostate cancer. J. Cell. Biochem. 91(3), 528-239 (2004).