Surfactant Protein A (C-Term) Rabbit Monoclonal Antibody (Clone RM334)

Surfactant protein A (SP-A) is a hydrophilic surfactant protein and member of the collectin family with roles in microbial and apoptotic cell phagocytosis, as well as the regulation of cytokine expression.^1,2,3,4 It is composed of an N-terminal cysteine-rich domain that facilitates crosslinking of SP-A monomers, a collagen-like domain that induces multimerization, and a C-terminal carbohydrate recognition domain (CRD) for pathogen recognition. SP-A is expressed primarily in pulmonary surfactant but is also expressed in the brain, kidney, and female reproductive tract.⁴ It functions as an octadecamer that binds bacterial, fungal, and viral pathogens to enhance opsonized phagocytosis. SP-A interacts with toll-like receptors to modulate the production of various cytokines and inflammatory mediators in response to infection.^1,2,3,4 Serum levels of SP-A are associated with early relapse or exacerbation in patients with chronic obstructive pulmonary disease (COPD).⁴ Cayman’s Surfactant Protein A (C-Term) Rabbit Monoclonal Antibody (Clone RM334) can be used for immunohistochemistry (IHC) and Western blot (WB) applications.

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1. Wright, J.R. Immunoregulatory functions of surfactant proteins. Nat. Rev. Immunol. 5(1), 58-68 (2005).

2. Nayak, A., Dodagatta-Marri, E., Tsolaski, A.G., et al. An insight into the diverse roles of surfactant proteins, SP-A and SP-D in innate and adaptive immunity. Front Immunol. 3, 131 (2012).

3. Watson, A., Phipps, M.J.S., Clark, H.W., et al. Surfactant proteins A and D: Trimerized innate immunity proteins with an affinity for viral fusion proteins. J. Innate Immun. 11(1), 13-28 (2019).

4. King, S.D., and Chen, S.-Y. Recent progress on surfactant protein A: cellular function in lung and kidney disease development. Am. J. Physiol. Cell Physiol. 319(2), C316-C320 (2020).