Cytokeratin 17 (C-Term) Rabbit Monoclonal Antibody (Clone RM351)

Cytokeratin 17 (CK-17) is an intermediate filament protein and a member of the cytokeratin protein family encoded by KRT17 in humans.¹ It is a type I acidic cytokeratin expressed in the basal cells of epithelial appendages, such as hair follicles and sebaceous glands, and is localized to the cytoplasm. CK-17 expression can be induced in the epidermis under conditions of cellular stress, such as viral infection, injury, or psoriasis. CK-17 is also expressed in squamous, basal, and urothelial carcinomas, as well as adenocarcinomas, and is associated with poor prognosis in breast, cervical, oral squamous, and gastric carcinomas.^1,2 Heterozygous dominant mutations in KRT17 are associated with early onset alopecia.¹ Missense mutations in KRT17 are associated with ectodermal dysplasias, including pachyonychia congenita and steatocystoma multiplex. Cayman’s Cytokeratin 17 (C-Term) Rabbit Monoclonal Antibody (Clone RM351) can be used for immunohistochemistry (IHC) and Western blot (WB) applications.

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1. Yang, L., Zhang, S., and Wang, G. Keratin 17 in disease pathogenesis: From cancer to dermatoses. J. Pathol. 247(2), 158-165 (2019).

2. Kim, K., Lee, H.W., Chae, S.W., et al. Cytokeratin 17 expression is associated with poor prognosis in gallbladder adenocarcinoma. Appl. Immunohistochem. Mol. Morphol. 25(5), 346-350 (2017).