GST3/GST-Pi (C-Term) Rabbit Monoclonal Antibody (Clone RM347)

Glutathione S-transferase 3 (GST3), also known as GST-Pi, is an enzyme that catalyzes the conjugation of glutathione (GSH) to the electrophilic center of various phase I toxic xenobiotic metabolites, facilitating their excretion by phase III membrane channels, transporters, and pumps.¹ It functions as a homodimer, with each monomer containing an N-terminal GSH-binding domain and a C-terminal domain with a hydrophobic cavity (H-site) for toxic compound binding. GST3 is expressed primarily in erythrocytes, as well as in the brain, heart, lung, testis, skin, kidney, pancreas, and saliva. GST3 dimers can bind a nitric oxide (NO) carrier, such as S-nitrosoglutathione or dinitrosyl-diglutathionyl-iron complex (DNDGIC), with one active site, indicating a role in the storage and transport of NO, while maintaining detoxification activity in the second active site.² Expression of GSTP1, the gene encoding GST3, is increased in patients with advanced-stage chronic kidney disease. GSTP1 polymorphisms are associated with increased risk of Parkinson's disease following exposure to cigarette smoke or pesticides, as well as with amyotrophic lateral sclerosis. Cayman's GST3/GST-Pi (C-Term) Rabbit Monoclonal Antibody (Clone RM347) can be used for immunohistochemistry (IHC) and Western blot (WB) applications.

WARNING This product is not for human or veterinary use.

1. Bocedi, A., Noce, A., Marrone, G., et al. Glutathione Transferase P_1-1 an enzyme useful in biomedicine and as biomarker in clinical practice and in environmental pollution. Nutrients 11(8), 1741 (2019).

2. Lo Bello, M., Nuccetelli, M., Caccuri, A.M., et al. Human glutathione transferase P_1-1 and nitric oxide carriers: A new role for an old enzyme. J. Bio. Chem. 276(45), (2001).