For immunochemical detection of stathmin
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Stathmin 1 (C-Term) Rabbit Monoclonal Antibody (Clone RM350)

Item No. 32281

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Synonyms
  • Leukemia-associated Phosphoprotein p18
  • Metablastin
  • Oncoprotein 18
  • Op18
  • STMN1
Immunogen
Peptide from the C-terminal region of human stathmin 1
Clone Designation
RM350
Formulation (Request formulation change)
100 µl of protein A-affinity purified monoclonal antibody
Storage Buffer
PBS with 50% glycerol, 1% BSA, and 0.09% sodium azide
Host
Rabbit
Isotype
IgG
Applications
IHC, WB
Cross Reactivity
(+) Stathmin 1
Species Reactivity
(+) Human
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

    100 µl

    $411

    Add
    Cayman Chemical
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    Product Description

    Stathmin 1 is a microtubule-destabilizing phosphoprotein and the founding member of the stathmin family of proteins.1,2 It is composed of a stathmin-like domain (SLD) that contains an N-terminal domain, a proline-rich domain, and two tubulin-binding repeats, which each bind one tubulin αβ heterodimer.2 Stathmin 1 also contains several phosphorylation sites which, when phosphorylated, negatively regulate its interaction with tubulin. It is ubiquitously expressed, with high levels in the nervous system, and localizes to the cytoplasm. Stathmin 1 binds to tubulin in a phosphorylation-dependent manner and regulates microtubule dynamics by promoting destabilization or preventing polymerization.2,3 Stathmin 1 is inactivated prior to mitosis and reactivated by dephosphorylation near the end of mitosis.3 STMN1, the gene encoding stathmin, is overexpressed in a variety of cancers and is associated with metastasis and poor prognosis.1,4 Cayman’s Stathmin (C-Term) Rabbit Monoclonal Antibody (Clone RM350) can be used for immunohistochemistry (IHC) and Western blot (WB) applications.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Belletti, B., and Baldassarre, G. Stathmin: A protein with many tasks. New biomarker and potential target in cancer. Expert Opin. Ther. Targets 15(11), 1249-1266 (2011).

    2. Chauvin, S., and Sobel, A. Neuronal stathmins: A family of phosphoproteins cooperating for neuronal development, plasticity and regeneration. Prog. Neurobiol. 126, 1-18 (2015).

    3. Rubin, C.I., and Atweh, G.F. The role of stathmin in the regulation of the cell cycle. J. Cell. Biochem. 93(2), 242-250 (2004).

    4. Biaoxue, R., Hua, L., Wenlong, G., et al. Overexpression of stathmin promotes metastasis and growth of malignant solid tumors: A systemic review and meta-analysis. Oncotarget 7(48), 78994-79007 (2016).