For immunochemical detection of p120-catenin
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p120-Catenin (C-Term) Rabbit Monoclonal Antibody (Clone RM353)

Item No. 32283

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Synonyms
  • Catenin (Cadherin-associated Protein) Delta 1
  • Delta-Catenin
Immunogen
Peptide from the C-terminal region of human p120-catenin
Clone Designation
RM353
Formulation (Request formulation change)
100 µl of protein A-affinity purified monoclonal antibody
Storage Buffer
PBS with 50% glycerol, 1% BSA, and 0.09% sodium azide
Host
Rabbit
Isotype
IgG
Applications
IHC, WB
Cross Reactivity
(+) p120-Catenin
Species Reactivity
(+) Human
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    100 µl

    $411

    Add
    Cayman Chemical
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    Product Description

    p120-Catenin is a member of the armadillo repeat domain protein family with roles in cell adhesion and junction maturation, as well as in the regulation of Rho family GTPase activity.1 Alternative splicing of CTNND1 pre-mRNA produces 64 isoforms with isoform 1 and 3 most commonly expressed.2,3 p120 isoform 1 is composed of an N-terminal coiled-coil domain, a regulatory domain, an armadillo repeat domain that facilitates cadherin interaction, and a C-terminal tail and is expressed in mesenchymal and non-epithelial cells. p120-Catenin isoform 3 lacks the N-terminal coiled-coil domain and is primarily expressed in epithelial cells.2 p120-Catenin is localized in three subcellular pools, a membrane-associated cadherin-bound pool, a cytoplasmic pool that modulates Rho GTPases, and a nuclear pool that associates with the transcriptional repressor Kaiso.3 Isoform switching from p120 isoform 3 to isoform 1 is coordinated with the E-cadherin to N-cadherin switch that occurs during epithelial-to-mesenchymal transition (EMT). Loss of CTNND1 expression is positively correlated with disease activity in patients with active Crohn's disease or ulcerative colitis.4 Increased levels of cytoplasmic p120-catenin are correlated with late-stage disease, lymph node metastasis, and reduced survival in patients with colorectal cancer, as well as poor prognosis in patients with lung squamous cell carcinoma and adenocarcinoma.1 Cayman's p120-Catenin (C-Term) Rabbit Monoclonal Antibody (Clone RM353) can be used for immunohistochemistry (IHC) and Western blot (WB) applications.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Kourtidis, A., Ngok, S.P., and Anastasiadis, P.Z. p120 catenin: An essential regulator of cadherin stability, adhesion-induced signaling, and cancer progression. Prog. Mol. Biol. Transl. Sci. 116, 409-432 (2013).

    2. Carnahan, R.H., Rokas, A., Gaucher, E.A., et al. The molecular evolution of the p120-catenin subfamily and its functional associations. PLoS One 5(12), e15747 (2010).

    3. Hu, G. p120-Catenin: A novel regulator of innate immunity and inflammation. Crit. Rev. Immunol. 32(2), 127-138 (2012).

    4. Karayiannakis, A.J., Syrigos, K.N., Efstathiou, J., et al. Expression of catenins and E-cadherin during epithelial restitution in inflammatory bowel disease. J. Pathol. 185(4), 413-418 (1998).