For immunochemical detection of cytokeratin 4
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Cytokeratin 4 (C-Term) Rabbit Monoclonal Antibody (Clone RM355)

Item No. 32285

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Synonyms
  • CK-4
  • Keratin-4
  • Keratin, Type II Cytoskeletal 4
  • KRT4
Immunogen
Peptide from the C-terminal region of human cytokeratin 4
Clone Designation
RM355
Formulation (Request formulation change)
100 µl of protein A-affinity purified monoclonal antibody
Storage Buffer
PBS with 50% glycerol, 1% BSA, and 0.09% sodium azide
Host
Rabbit
Isotype
IgG
Applications
IHC, WB
Cross Reactivity
(+) Cytokeratin 4
Species Reactivity
(+) Human
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

    100 µl

    $411

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    Product Description

    Cytokeratin 4 is a type II epithelial intermediate filament protein.1 It is composed of a central rod containing four α-helical domains, which are important for self-assembly, and non-helical head and tail domains at the N- and C-termini, respectively. Cytokeratin 4 is expressed in mucosal stratified squamous epithelial cells, columnar luminal cells of the respiratory epithelium, and in non-stratified simple epithelial cells, with the highest expression in the esophagus and cornea.2 Cytokeratin 4 dimerizes with the type I epithelial intermediate filament protein cytokeratin 13, with the dimers then combining to form tetramers.1,2 Mice lacking Krt4, the gene encoding cytokeratin 4, have disruptions in the epithelial integrity of the esophagus, tongue, and cornea, including basal hyperplasia, lack of cell maturation, and hyperkeratosis.3 Mutations in KRT4 have been associated with white sponge nevus, a disorder characterized by thickened white, spongy plaques on the oral mucosa.2 Cayman’s Cytokeratin 4 (C-Term) Rabbit Monoclonal Antibody (Clone RM355) can be used for immunohistochemistry (IHC) and Western blot applications.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Gu, L.-H., and Coulombe, P.A. Keratin function in skin epithelia: A broadening palette with surprising shades. Curr. Opin. Cell Biol. 19(1), 13-23 (2007).

    2. Moll, R., Divo, M., and Langbein, L. The human keratins: biology and pathology. Histochem. Cell Biol. 129(6), 705-733 (2008).

    3. Ness, S.L., Edelmann, W., Jenkins, T.D., et al. Mouse keratin 4 is necessary for internal epithelial integrity. The Journal of Biological Chemisty 273(37), 23904-23911 (1998).