For immunochemical detection of cytokeratin 19
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Cytokeratin 19 (C-Term) Rabbit Monoclonal Antibody (Clone RM364)

Item No. 32289

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Synonyms
  • CK-19
  • Keratin, Type I Cytoskeletal 19
  • Keratin-19
  • KRT19
Immunogen
Peptide from the C-terminal region of human cytokeratin 19
Clone Designation
RM364
Formulation (Request formulation change)
100 µl of protein A-affinity purified monoclonal antibody
Storage Buffer
PBS with 50% glycerol, 1% BSA, and 0.09% sodium azide
Host
Rabbit
Isotype
IgG
Applications
IHC and WB
Cross Reactivity
(+) Cytokeratin 19
Species Reactivity
(+) Human
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

    100 µl

    $411

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    Cayman Chemical
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    Product Description

    Cytokeratin 19 is a type I epithelial intermediate filament protein.1 It is composed of a central rod containing four α-helical domains, which are important for self-assembly, and non-helical head and tail domains at the N- and C-termini, respectively. Cytokeratin 19 is expressed in bile duct epithelial cells and non-keratinized stratified squamous epithelial cells, as well as other epithelial cells.2 Cytokeratin 19 is associated with a variety of cancers, including salivary gland, lung, and thyroid papillary carcinomas and various gastrointestinal cancers.3 The presence of cytokeratin 19 in tumor tissue from patients with hepatocellular carcinoma is associated with reduced recurrence-free and overall survival.4 Cayman’s Cytokeratin 19 (C-Term) Rabbit Monoclonal Antibody (Clone RM364) can be used for immunohistochemistry (IHC) and Western blot (WB) applications.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Gu, L.-H., and Coulombe, P.A. Keratin function in skin epithelia: A broadening palette with surprising shades. Curr. Opin. Cell Biol. 19(1), 13-23 (2007).

    2. Chu, P.G., and Weiss, L.M. Keratin expression in human tissues and neoplasms. Histopathology 40(5), 403-439 (2002).

    3. Caviglia, G.P., Ciruolo, M., Olivero, A., et al. Prognostic role of serum cytokeratin-19 fragment (CYFRA 21-1) in patients with hepatocellular carcinoma. Cancers 12(10), 2776 (2020).

    4. Kawai, T., Yasuchika, K., Ishii, T., et al. Keratin 19, a cancer stem cell marker in human hepatocellular carcinoma. Clin. Cancer Res. 21(13), 3081-3091 (2015).