SATB2 (C-Term) Rabbit Monoclonal Antibody (Clone RM365)

Special AT-rich sequence-binding protein 2 (SATB2) is a transcription factor.¹ It is composed of two CUT domains and a homeobox domain, which bind DNA matrix attachment regions (MARs) and promote chromatin remodeling.^1,2 SATB2 is expressed in superficial cortical layers during embryonic development, where it regulates the formation of callosal projection neurons by repressing Ctip2 expression, and by hippocampal and cortical pyramidal neurons in the adult brain, where it has roles in synaptic plasticity and neurotransmission.^3,2 It has additional functions in B cell and osteoblast differentiation.² SATB2 has been used as a marker for primary or metastatic colorectal cancer.⁴ SATB2 variants have been found in patients with SATB2-associated syndrome, an autosomal dominant disorder characterized by intellectual disability and craniofacial abnormalities, as well as in patients with schizophrenia.^1,5 Cayman's SATB2 (C-Term) Rabbit Monoclonal Antibody (Clone RM365) can be used for immunohistochemistry (IHC) and Western blot (WB) applications.

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1. Zarate, Y.A., Bosanko, K.A., Caffrey, A.R., et al. Mutation update for the SATB2 gene. Hum. Mutat. 40(8), 1013-1029 (2019).

2. Alcamo, E.A., Chirivella, L., Dautzenberg, M., et al. Satb2 regulates callosal projection neuron identity in the developing cerebral cortex. Neuron 57(3), 364-377 (2008).

3. Cera, I., Whitton, L., Donohoe, G., et al. Genes encoding SATB2-interacting proteins in adult cerebral cortex contribute to human cognitive ability. PLoS Genet. 15(2), e1007890 (2019).

4. Zhang, Y.-J., Chen, J.-W., He, X.-S., et al. SATB2 is a promising biomarker for identifying a colorectal origin for liver metastatic adenocarcinomas. EBioMedicine 28, 62-69 (2018).

5. Zhou, J., Chen, J., Xu, W., et al. Common variants in SATB2 are associated with schizophrenia in Uygur Chinese population. Psychiatr. Genet. 29(4), 120-126 (2018).