For immunochemical detection of napsin A
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Napsin A (N-Term) Rabbit Monoclonal Antibody (Clone RM366)

Item No. 32291

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Synonyms
  • Kidney-derived Aspartic Protease-like Protein
  • NAPA
  • Napsin A Aspartic Peptidase
  • Napsin-1
Immunogen
Peptide from the N-terminal region of human napsin A
Clone Designation
RM366
Formulation (Request formulation change)
100 µl of protein A-affinity purified monoclonal antibody
Storage Buffer
PBS with 50% glycerol, 1% BSA, and 0.09% sodium azide
Host
Rabbit
Isotype
IgG
Applications
IHC, WB
Cross Reactivity
(+) Napsin A
Species Reactivity
(+) Human
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

    100 µl

    $411

    Add
    Cayman Chemical
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    Product Description

    Napsin A is an aspartic protease.1,2 It is composed of an N-terminal signaling peptide, a prodomain, and a single protein chain, which shares 40 to 50% sequence homology with cathepsins D and E and contains an 18 amino acid C-terminal extension.2 Napsin A is expressed in the renal cortex and outer medulla, alveolar macrophages, and type I pneumocytes, as well as type II pneumocytes, where it has a role in surfactant protein processing.2,3 Napsin A is found in patient-derived lung adenocarcinomas and nephrogenic adenomas but not lung small cell or thyroid carcinomas.4,5 Cayman’s Napsin A (N-Term) Rabbit Monoclonal Antibody (Clone RM366) can be used for immunohistochemistry (IHC) and Western blot (WB) applications.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Schauer-Vukasinovic, V., Bur, D., Kling, D., et al. Human napsin A: Expression, immunochemical detection, and tissue localization. FEBS Lett. 462(1-2), 135-139 (1999).

    2. Giller, T., and Schauer-Vukasinovic, V. Naspin A. Handbook of proteolytic enzymes 1, (2004).

    3. Brasch, F., Ochs, M., Kahne, T., et al. Involvement of napsin A in the C- and N-terminal processing of surfactant protein B in type-II pneumocytes of the human lung. The Journal of Biological Chemisty 278(49), 49006-49014 (2003).

    4. Turner, B.M., Cagle, P.T., Sainz, I.M., et al. Napsin A, a new marker for lung adenocarcinoma, is complementary and more sensitive and specific than thyroid transcription factor 1 in the differential diagnosis of primary pulmonary carcinoma: Evaluation of 1674 cases by tissue microarray. Arch. Pathol. Lab. Med. 136(2), 163-171 (2012).

    5. Sharifai, N., Abro, B., Chen, J.-F., et al. Napsin A is a highly sensitive marker for nephrogenic adenoma: An immunohistochemical study with a specificity test in genitourinary tumors. Hum. Pathol. 102, 23-32 (2020).