For immunochemical detection of syntaxin-1A
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Syntaxin-1A Rabbit Monoclonal Antibody (Clone RM367)

Item No. 32292

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Synonyms
  • Hemolysin Co-regulated Protein 1
  • HPC-1
  • Stx-1A
Immunogen
Peptide corresponding to residues near the N-terminal of human syntaxin-1A
Clone Designation
RM367
Formulation (Request formulation change)
100 µl of protein A-affinity purified monoclonal antibody
Storage Buffer
PBS, with 50% glycerol, 1% BSA, and 0.09% sodium azide
Host
Rabbit
Isotype
IgG
Applications
IHC, WB
Cross Reactivity
(+) Human syntaxin-1A
Species Reactivity
(+) Human(+) Mouse(+) Rat
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

    100 µl

    $411

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    Product Description

    Syntaxin-1A is a type II integral membrane protein and member of the SNARE complex that has a major role in neuronal exocytosis.1,2 It is composed of a cytoplasmic N-terminal regulatory domain, a coiled-coil SNARE domain that mediates protein-protein interactions, and a C-terminal transmembrane tail that is required for membrane localization.3,4 Syntaxin-1A is located primarily on neuronal plasma membranes and associates with synaptosomal-associated protein 25 (SNAP-25), vesicle-associated membrane protein (VAMP), and the syntaxin-binding protein Munc18 to form the SNARE complex, which facilitates synaptic vesicle docking and neurotransmitter release in a calcium-dependent manner.1,5 It is also found in pancreatic β cells, where it is involved in insulin secretion, as well as in the heart.6,7 STX1A SNPs have been found in patients with Asperger syndrome, attention-deficit hyperactivity disorder (ADHD), or coronary artery disease.7,8,9 Cayman's Syntaxin-1A Rabbit Monoclonal Antibody (Clone RM367) can be used for immunohistochemistry (IHC) and Western blot (WB) applications.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Karmakar, S., Sharma, L.G., Roy, A., et al. Neuronal SNARE complex: A protein folding system with intricate protein-protein interactions, and its common neuropathological hallmark, SNAP25. Neurochem. Int. 122, 196-207 (2019).

    2. Lerman, J.C., Robblee, J., Fairman, R., et al. Structural analysis of the neuronal SNARE protein syntaxin-1A. Biochemistry 39(29), 8470-8479 (2000).

    3. Harbury, P.A. Springs and zippers: Coiled coils in SNARE-mediated membrane fusion. Structure 6(12), 1487-1491 (1998).

    4. Teng, F.Y., Wang, Y., and Tang, B.L. The syntaxins. Genome Biol. 2(11), 3012.3011-3012.3017 (2001).

    5. Südhof, T.C. Calcium control of neurotransmitter release. Cold Spring Harb. Perspect. Biol. 4(1), a011353 (2012).

    6. Liang, T., Qin, T., Xie, L., et al. New roles of syntaxin-1A in insulin granule exocytosis and replenishment. The Journal of Biological Chemisty 292(6), 2203-2216 (2017).

    7. Guerini, F.R., Ripamonti, E., Costa, A.S., et al. The Syntaxin-1A gene single nucleotide polymorphism rs4717806 associates with the risk of ischemic heart disease. Medicine (Baltimore) 98(24), e15846 (2019).

    8. Durdiaková, J., Warrier, V., Banerjee-Basu, S., et al. STX1A and Asperger syndrome: A replication study. Mol. Autism 5(1), 14 (2014).

    9. Wang, M., Gu, X., Huang, X., et al. STX1A gene variations contribute to the susceptibility of children attention-deficit/hyperactivity disorder: A case-control association study. Eur. Arch. Psychiatry Clin. Neurosci. 269(6), 689-699 (2019).