For immunochemical detection of surfactant protein B
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Surfactant Protein B Rabbit Monoclonal Antibody (Clone RM370)

Item No. 32295

Product Insert (PDF)
Technical Information
Synonyms
  • SP-B
Immunogen
Peptide corresponding to residues near the C-terminus of human surfactant protein B
Clone Designation
RM370
Formulation (Request formulation change)
100 µl of protein A-affinity purified monoclonal antibody
Storage Buffer
PBS with 50% glycerol, 1% BSA, and 0.09% sodium azide
Host
Rabbit
Isotype
IgG
Applications
IHC, WB
Cross Reactivity
(+) proSP-B(+) Surfactant protein B
Species Reactivity
(+) Human
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    100 µl

    $411

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    Product Description

    Surfactant protein B (SP-B) is a hydrophobic surfactant protein and member of the saposin-like family encoded by SFTBP in humans.1 Mature SP-B is a 79-amino acid peptide formed by cleavage of proSP-B that contains three intramolecular disulfide bridges, which stabilize the tertiary structure. SP-B is expressed in alveolar type II cells, functions as a homodimer formed via intermolecular disulfide bond formation, and is required for the assembly of pulmonary surfactant, as well as the formation of stable surface-active films at the air-liquid alveolar interface. Blood levels of SB-P are increased in patients with mechanical ventilation- or pulmonary edema-induced acute alveolar cell damage.1,2 Mutations in SFTBP induce SP-B deficiency, an autosomal recessive disorder in infants characterized by progressive hypoxemic respiratory failure in the first year of life.3 Cayman’s Surfactant Protein B Rabbit Monoclonal Antibody (Clone RM370) can be used for immunohistochemistry (IHC) and Western blot (WB) applications.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Banfi, C., and Agostoni, P. Surfactant protein B: From biochemistry to its potential role as diagnostic and prognostic marker in heart failure. Int. J. Cardiol. 221, 456-462 (2016).

    2. Dobbe, L., Rahman, R., Elmassry, M., et al. Cardiogenic Pulmonary Edema. Am. J. Med. Sci. 358(6), 389-397 (2019).

    3. Wilder, M.A. Surfactant protein B deficiency in infants with respiratory failure. J. Perinat. Neonatal Nurs. 18(1), 61-67 (2004).