For immunochemical detection of CR2
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CR2/CD21 (C-Term) Rabbit Monoclonal Antibody (Clone RM372)

Item No. 32297

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Synonyms
  • Complement Receptor 2
  • Epstein Barr Virus Receptor, Complement C3d Receptor
  • C3DR
Immunogen
Peptide from the C-terminal region of human CR2
Clone Designation
RM372
Formulation (Request formulation change)
100 µl of protein A-affinity purified monoclonal antibody
Storage Buffer
PBS with 50% glycerol, 1% BSA, and 0.09% sodium azide
Host
Rabbit
Isotype
IgG
Applications
IHC, WB
Cross Reactivity
(+) CR2
Species Reactivity
(+) Human
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    100 µl

    $411

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    Cayman Chemical
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    Product Description

    Complement receptor 2 (CR2), also known as CD21, is a type I transmembrane glycoprotein with a role in the complement system.1 It is composed of an extracellular domain that contains 15 or 16 short consensus repeats involved in stabilizing the triple-loop domain conformation, a transmembrane domain, and a short cytoplasmic domain containing one PKC and one tyrosine kinase phosphorylation site. CR2 is primarily expressed on mature B cells and follicular dendritic cells (FDCs) but is also expressed on the pharyngeal and cervical epithelium, thymocytes, and a subset of peripheral T cells.1,2 It forms a complex with CD19, TAPA-1, and Leu-19 on the surface of B cells, where it acts as a ligand-fixing subunit that binds surface-fixed cleavage fragments of complement protein C3 on antigen presenting cells to amplify antigen-induced B cell activation and antibody production.1 CR2 is also a receptor for Epstein Barr Virus. B cell levels of CR2 are decreased in patients with systemic lupus erythematosus (SLE).3 Cayman’s CR2/CD21 (C-Term) Rabbit Monoclonal Antibody (Clone RM372) can be used for immunohistochemistry (IHC) and Western blot (WB) applications.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Frémeaux-Bacchi, V., Kolb, J.-P., Rakotobé, S., et al. Functional properties of soluble CD21. Immunopharmacology 42(1-3), 31-37 (1999).

    2. Jacobson, A.C., and Weis, J.H. Comparative functional evolution of human and mouse CR1 and CR2. J. Immunol. 181(5), 2953-2959 (2008).

    3. Boackle, S.A. Complement and autoimmunity. Biomed. Pharmacother. 57, 269–273 (2003).