For immunochemical detection of TTF1
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TTF1 Rabbit Monoclonal Antibody (Clone RM373)

Item No. 32298

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Synonyms
  • NK2 homeobox 1
  • NKX2-1
  • Thyroid Transcription Factor-1
Immunogen
Peptide corresponding to a region near the N-terminal region of human TTF1
Clone Designation
RM373
Formulation (Request formulation change)
100 µl of protein A-affinity purified monoclonal antibody
Storage Buffer
PBS, with 50% glycerol, 1% BSA, and 0.09% sodium azide
Host
Rabbit
Isotype
IgG
Applications
IHC, WB
Cross Reactivity
(+) TTF1
Species Reactivity
(+) Human
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    100 µl

    $411

    Add
    Cayman Chemical
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    Product Description

    Thyroid transcription factor-1 (TTF1) is a member of the NKX2 transcription factor family.1,2 It is expressed in the thyroid, pulmonary epithelium, and hypothalamus, and localized to the nucleus, where it functions as a lineage regulator inducing tissue-specific gene expression.1,3 TTF1 is expressed in the majority of lung adenocarcinomas, acting as a lineage survival oncogene.2 However, it also functions as a tumor suppressor and is positively correlated with favorable outcomes in patients with non-small cell lung cancer (NSCLC).2,3 TTF1 is expressed in some breast and ovarian cancers and is correlated with high grade and poorer disease-specific survival, respectively.3 Cayman’s TTF1 Rabbit Monoclonal Antibody (Clone RM373) can be used for immunohistochemistry (IHC) and Western blot (WB) applications.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Aversa, S., and Bellan, C. TTF1 expression in pulmonary metastatic rectal adenocarcinoma. Case Rep. Gastrointest. Med. 6405125 (2018).

    2. Yoshimura, K., Inoue, Y., Mori, K., et al. Distinct prognostic roles and heterogeneity of TTF1 copy number and TTF1 protein expression in non-small cell lung cancer. Genes Chromosomes Cancer 56(7), 570-581 (2017).

    3. Phelps, C.A., Lai, S.-C., and Mu, D. Roles of thyroid transcription factor 1 in lung cancer biology. Vitman. Horm. 106, 517-544 (2018).