For immunochemical detection of integrin β3
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Integrin β3/CD61 Rabbit Monoclonal Antibody (Clone RM382)

Item No. 32310

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Synonyms
  • GP3A
  • GPIIIa
  • Platelet Glycoprotein IIIa
Immunogen
Peptide corresponding to the internal region of human integrin β3
Clone Designation
RM382
Formulation (Request formulation change)
100 µl of protein A-affinity purified monoclonal antibody
Storage Buffer
PBS, with 50% glycerol, 1% BSA, and 0.09% sodium azide
Host
Rabbit
Isotype
IgG
Applications
IHC, WB
Cross Reactivity
(+) Integrin β3
Species Reactivity
(+) Human
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    100 µL

    $411

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    Product Description

    Integrins are cell adhesion receptors that mediate the attachment of cells to the extracellular matrix (ECM) and facilitate cell-cell interactions.1 The integrin family contains 18 α subunits and eight β subunits that form 24 different heterodimers grouped into familial subgroups based on subunit composition and/or their ligand binding properties. Integrin β3, also known as CD61, is an integrin subunit that associates with αIIB or αv integrin subunits, forming αIIBβ3 and αvβ3 integrin heterodimers, respectively, which function as receptors for a variety of ECM proteins, including fibrinogen, fibronectin, and collagen and mediate outside-in and inside-out signaling cascades.2,3,4 Integrin β3 is composed of a ligand-binding extracellular domain, a single transmembrane segment, and a short cytoplasmic tail.3 It is expressed by platelets, megakaryocytes, and endothelial cells, as well as monocytes and macrophages. Mutations in ITGB3 have been found in patients with Glanzmann thrombasthenia, a hemorrhagic disease characterized by defects in platelet function, and ITGB3 SNPs are associated with increased risk of myocardial infarction.2 Cayman's Integrin β3/CD61 Rabbit Monoclonal Antibody (Clone RM382) can be used for immunohistochemistry (IHC) and Western blot (WB) applications.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Barczyk, M., Carracedo, S., and Gullberg, D. Integrins. Cell Tissue Res. 339(1), 269-280 (2010).

    2. Jiménez-Marín, A., Yubero, N., Esteso, G., et al. Molecular characterization and expression analysis of the gene coding for the porcine β3 integrin subunit (CD61). Gene 408(1-2), 9-17 (2008).

    3. Moreno, A., C., L., Llanes, D., et al. Role of CD-61 (β-3 lntegrin) glycoprotein in colon carcinoma. Handbook of Immunohistochemistry and in Situ Hybridization of Human Carcinomas 2, 227-235 (2002).

    4. Mehrdad, M., Trisno, S., and Mofrad, R.K. On the activation of integrin αIIbβ3: Outside-in and inside-out pathways. Biophys. J. 105(6), 1304-1315 (2013).