For immunochemical detection of cytokeratin 10
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Cytokeratin 10 (C-Term) Rabbit Monoclonal Antibody (Clone RM386)

Item No. 32313

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Synonyms
  • CK-10
  • Keratin-10
  • Keratin, Type I Cytoskeletal 10
  • KRT10
Immunogen
Peptide from the C-terminal region of human cytokeratin 10
Clone Designation
RM386
Formulation (Request formulation change)
100 µl of Protein A-affinity purified monoclonal antibody
Storage Buffer
PBS, with 50% glycerol, 1% BSA, and 0.09% sodium azide
Host
Rabbit
Isotype
IgG
Applications
IHC, WB
Cross Reactivity
(+) Cytokeratin 10
Species Reactivity
(+) Human
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    100 µl

    $411

    Add
    Cayman Chemical
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    Product Description

    Cytokeratin 10 (CK-10) is a type I acidic epithelial intermediate filament protein.1 It is composed of a central rod containing four α-helical domains, which are important for self-assembly, and non-helical head and tail domains at the N- and C-termini, respectively.2 CK-10 expression is induced upon keratinocyte differentiation, increasing during keratinocyte migration from the basal layer to the suprabasal layer of the epidermis.1 It dimerizes with the type II epithelial intermediate filament protein CK-1 via heptad repeats in the central rod domain to form a network of filament bundles throughout the cytoplasm.3 Increased tumor CK10 expression has been found in patients with hepatocellular carcinoma (HCC) and is associated with poor prognosis.4 CK10 mutations have been found in patients with epidermolysis bullosa simplex (EBS), a disorder characterized by skin blistering.3 Cayman's Cytokeratin 10 (C-Term) Rabbit Monoclonal Antibody (Clone RM386) can be used for immunohistochemistry (IHC) and Western blot (WB) applications.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Moll, R., Divo, M., and Langbein, L. The human keratins: biology and pathology. Histochem. Cell Biol. 129(6), 705-733 (2008).

    2. Gu, L.-H., and Coulombe, P.A. Keratin function in skin epithelia: A broadening palette with surprising shades. Curr. Opin. Cell Biol. 19(1), 13-23 (2007).

    3. Chan, Y.M., Yu, Q.C., LeBlanc-Straceski, J., et al. Mutations in the non-helical linker segment L1-2 of keratin 5 in patients with Weber-Cockayne epidermolysis bullosa simplex. J. Cell Sci. 107(Pt 4), 765-774 (1994).

    4. Yang, X.-R., Xu, Y., Shi, G.-M., et al. Cytokeratin 10 and cytokeratin 19: Predictive markers for poor prognosis in hepatocellular carcinoma patients after curative resection. Clin. Cancer Res. 14(12), 3850-3859 (2008).