ΔNp63 (N-Term) Rabbit Monoclonal Antibody (RM392)

p63 is a transcription factor and member of the p53 gene family encoded by TP63 in humans.^1,2 Alternative promoter use and splicing of TP63 mRNA produces several variants, including α, β, γ, δ, and ε isoforms in full-length or N-terminally truncated forms known as TAp63 and ΔNp63, respectively. ΔNp63 is expressed in kidney, spleen, thymus, and epithelia but not the heart, liver, testes, or brain and is localized to the cytosol as a tetramer.² It is activated in response to various signaling pathways, including EGFR, Wnt, and NF-kB, and has roles in cell survival, senescence, stemness, and metabolism, as well as oncogenesis. ΔNp63 levels are positively correlated with poor response to chemotherapeutics in various cancers. N- and C-terminal mutations in ΔNp63 are associated with epidermal defects and skin fragility in patients with ankyloblepharon ectodermal dysplasia and clefting (AEC).^2,3 Cayman's ΔNp63 (N-Term) Rabbit Monoclonal Antibody (RM392) can be used for immunohistochemistry (IHC).

WARNING This product is not for human or veterinary use.

1. Soares, E., and Zhou, H. Master regulatory role of p63 in epidermal development and disease. Cell. Mol. Life Sci. 75(7), 1179-1190 (2017).

2. Fisher, M.L., Balinth, S., and Mills, A.A. p63-related signaling at a glance. J. Cell Sci. 133(17), jcs228015 (2020).

3. Koster, M.I., Marinari, B., Payne, A.S., et al. ΔNp63 knockdown mice: A mouse model for AEC syndrome. Am. J. Med. Genet. A. 149A(9), 1942-1947 (2009).