CD1a (N-Term) Rabbit Monoclonal Antibody (RM393)

CD1a is a transmembrane glycoprotein and member of the CD1 family.¹ CD1a exists as a heterodimer where each monomer is composed of a transmembrane CD1 heavy chain that contains three extracellular domains (α1-α3), which associate with β2-microglobulin to form a lipid-binding groove, as well as a short cytoplasmic tail that lacks the typical CD1 family tyrosine-containing hydrophobic motif that localizes other CD1 molecules to endosomes and lysosomes.² It is primarily expressed on, and has been used as a marker for, dendritic cells and is also expressed on thymocytes and Langerhans cells and localizes to the cell surface.^1,2 CD1a binds to self- and foreign lipids and glycolipids and presents them to group 1 CD1-restricted T cells.¹ It is a receptor for urushiol, a plant-derived allergen, and mediates its inflammatory skin response, as well as the inflammation induced by self-lipid antigens in patients with psoriasis.³ The density of CD1a protein in patient-derived tumor tissue is associated with improved clinical outcomes and survival.¹ Cayman’s CD1a (N-Term) Rabbit Monoclonal Antibody (RM393) can be used for immunohistochemistry (IHC).

WARNING This product is not for human or veterinary use.

1. Coventry, B., and Heinzel, S. CD1a in human cancers: A new role for an old molecule. Trends Immunol. 25(5), 242-248 (2004).

2. Zajonc, D.M., Elsliger, M.A., Teyton, L., et al. Crystal structure of CD1a in complex with a sulfatide self antigen at a resolution of 2.15 Å. Nat. Immunol. 4(8), 808-815 (2003).

3. Kim, J.H., Hu, Y., Yongqing, T., et al. CD1a on Langerhans cells controls inflammatory skin disease. Nat. Immunol. 17(10), 1159-1166 (2016).