For immunochemical detection of FOXP1
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FOXP1 (C-Term) Rabbit Monoclonal Antibody (RM402)

Item No. 32328

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Synonyms
  • Forkhead Box P1
  • Glutamine-rich Factor 1
  • QRF1
Immunogen
Peptide from the C-terminal region of human FOXP1
Clone Designation
RM402
Formulation (Request formulation change)
100 µl of protein A-affinity purified monoclonal antibody
Storage Buffer
PBS with 50% glycerol, 1% BSA, and 0.09% sodium azide
Host
Rabbit
Isotype
IgG
Applications
IHC, WB
Cross Reactivity
(+) FOXP1​
Species Reactivity
(+) Human
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

    100 µl

    $411

    Add
    Cayman Chemical
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    Product Description

    Forkhead box P1 (FOXP1) is a member of the FOX family of transcription factors and a transcriptional repressor with roles in cardiac valve morphogenesis, B and T cell development, monocyte differentiation, and lung development.1 It is composed of an N-terminal polyglutamine tract, a zinc finger domain, a leucine zipper, and a C-terminal forkhead domain.1,2 FoxP1 is ubiquitously expressed and localized to the nucleus where it binds to DNA to regulate transcription. Increased expression of FOXP1 is associated with poor prognosis in patients with diffuse large B cell lymphoma (DLBCL).3 Mutations in FOXP1 are associated with language impairment, speech delay, and grammar defects in patients with autism spectrum disorder.2,4 Cayman’s FOXP1 (C-Term) Rabbit Monoclonal Antibody (RM402) can be used for immunohistochemistry (IHC) and Western blot (WB) applications.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Koon, H.B., Ippolito, G.C., Banham, A.H., et al. FOXP1: A potential therapeutic target in cancer. Expert Opin. Ther. Targets 11(7), 955-965 (2007).

    2. Bowers, J.M., and Konopka, G. The role of the FOXP family of transcription factors in ASD. Dis. Markers 33(5), 251-260 (2012).

    3. Tzankov, A., Zlobec, I., Went, P., et al. Prognostic immunophenotypic biomarker studies in diffuse large B cell lymphoma with special emphasis on rational determination of cut-off scores. Leuk. Lymphoma. 51(2), 199-212 (2010).

    4. Bacon, C., and Rappold, G.A. The distinct and overlapping phenotypic spectra of FOXP1 and FOXP2 in cognitive disorders. Hum. Genet. 131(11), 1687-1698 (2012).