For immunochemical detection of aminopeptidase N
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Aminopeptidase N/CD13 (C-Term) Rabbit Monoclonal Antibody (RM403)

Item No. 32329

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Synonyms
  • Alanine Aminopeptidase
  • APN
  • ANPEP
  • gp150
  • Microsomal Aminopeptidase
  • Particle-bound Aminopeptidase
Immunogen
Peptide from the C-terminal region of human aminopeptidase N
Clone Designation
RM403
Formulation (Request formulation change)
100 µl of protein A-affinity purified monoclonal antibody
Storage Buffer
PBS, with 50% glycerol, 1% BSA, and 0.09% sodium azide
Host
Rabbit
Isotype
IgG
Applications
IHC, WB
Cross Reactivity
(+) Aminopeptidase N
Species Reactivity
(+) Human
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

    100 µl

    $411

    Add
    Cayman Chemical
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    Product Description

    Aminopeptidase N, also known as cluster of differentiation 13 (CD13), is a zinc-dependent and membrane-bound ectopeptidase and type II membrane glycoprotein encoded by ANPEP in humans.1,2 It is composed of a short N-terminal cytosolic domain, a membrane-spanning domain, and five extracellular domains, including a C-terminal catalytic domain.2,3 It is ubiquitously expressed on cell membranes where it functions as a dimer to degrade peptides and proteins containing N-terminal neutral amino acids.2 Plasma levels of soluble aminopeptidase N are increased and positively correlated with tumor progression in patients with non-small cell lung cancer (NSCLC).1 ANPEP is overexpressed in psoriatic skin lesions, synovial fibroblasts isolated from patients with rheumatoid arthritis, and lymphocytes and peripheral blood mononuclear cells (PBMCs) isolated from patients with multiple sclerosis during acute exacerbation and chronic progression.2 Cayman’s Aminopeptidase N/CD13 (C-Term) Rabbit Monoclonal Antibody (RM403) can be used for immunohistochemistry (IHC) and Western blot (WB) applications.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Wickström, K., Larsson, R., Nygren, P., et al. Aminopeptidase N (CD13) as a target for cancer chemotherapy. Cancer Sci. 102(3), 501-508 (2011).

    2. Lu, C., Amin, M.A., and Fox, D.A. CD13/Aminopeptidase N Is a potential therapeutic target for inflammatory disorders. J. Immunol. 204(1), 3-11 (2020).

    3. Sjöström, H., Norén, O., and Olsen, J. Structure and function of aminopeptidase N. Adv. Exp. Med. Biol. 477, 25-34 (2000).