For immunochemical detection of MSH3
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MSH3 (N-Term) Rabbit Monoclonal Antibody (RM405)

Item No. 32331

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Synonyms
  • DNA Mismatch Repair Protein MSH3
  • Mismatch Repair Protein 1
  • MRP1
  • MutS Homolog 3
Immunogen
Peptide from the N-terminal region of human MSH3
Clone Designation
RM405
Formulation (Request formulation change)
100 µl of protein A-affinity purified monoclonal antibody
Storage Buffer
PBS, with 50% glycerol, 1% BSA, and 0.09% sodium azide
Host
Rabbit
Isotype
IgG
Applications
IHC, WB
Cross Reactivity
(+) MSH3
Species Reactivity
(+) Human
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

    100 µl

    $411

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    Product Description

    MutS homolog 3 (MSH3) is a DNA repair protein.1,2 It heterodimerizes with MSH2 to form the MutSβ complex, which is divided into mismatch-binding, connector, α-helical lever, clamp, ATPase, and dimerization domains.3 It is ubiquitously expressed and localized to the nucleus. MSH3, when complexed with MSH2, recognizes nucleotide insertion-deletion mismatches, as well as larger insertion-deletion loops, to activate MutL and initiate DNA repair.2 SNPs in MSH3 are associated with disease progression in patients with Huntington’s disease.4 Cayman’s MSH3 (N-Term) Rabbit Monoclonal Antibody (RM405) can be used for immunohistochemistry (IHC) and Western blot (WB) applications.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Stanisławska-Sachadyn, A., and Sachadyn, P. MutS as a tool for mutation detection. Acta Biochim. Pol. 52(3), 575-583 (2005).

    2. Guerrette, S., Wilson, T., Gradia, S., et al. Interactions of human hMSH2 with hMSH3 and hMSH2 with hMSH6: Examination of mutations found in hereditary nonpolyposis colorectal cancer. Mol. Cell. Biol. 18(11), 6616-6623 (1998).

    3. Sharma, M., Predeus, A.V., Kovacs, N., et al. Differential mismatch recognition specificities of eukaryotic MutS homologs, MutSα and MutSβ. Biophys J. 106(11), 2483-2492 (2014).

    4. Flower, M., Lomeikaite, V., Ciosi, M., et al. MSH3 modifies somatic instability and disease severity in Huntington’s and myotonic dystrophy type 1. Brain 142(7), 1876-1886 (2019).