For immunochemical detection of cytokeratin 7
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Cytokeratin 7 (C-Term) Rabbit Monoclonal Antibody (Clone RM416)

Item No. 32337

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Synonyms
  • CK-7
  • Keratin-7
  • Keratin, Type II Cytoskeletal 7
  • KRT7
Immunogen
Peptide from the C-terminal region of human cytokeratin 7
Clone Designation
RM416
Formulation (Request formulation change)
100 µl of protein A-affinity purified monoclonal antibody
Storage Buffer
PBS with 50% glycerol, 1% BSA, and 0.09% sodium azide
Host
Rabbit
Isotype
IgG
Applications
IHC and WB
Cross Reactivity
(+) Cytokeratin 7
Species Reactivity
(+) Human
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    100 µl

    $411

    Add
    Cayman Chemical
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    Product Description

    Cytokeratin 7 (CK-7) is an intermediate filament protein and a member of the cytokeratin protein family.1,2 It is a type II neutral-basic cytokeratin expressed in ductal, glandular, and transitional epithelial tissues, as well as endothelial cells, but not stratified squamous epithelia, and is localized to the cytoplasm.2,3 CK-7 is found in various tumors, including ductal, lobular, and mucinous carcinomas, as well as ovarian, but not colorectal, adenocarcinomas, malignant mesotheliomas, and transitional cell carcinomas.3 It is also found in chromophobe renal cell carcinomas but not oncocytoma and conventional carcinomas and has been used as a biomarker for differentiation of tumor origin.4 Hepatocyte expression of CK-7 is positively correlated with fibrosis stage in patients with hepatitis B and hepatitis C.5 Cayman’s Cytokeratin 7 (C-Term) Rabbit Monoclonal Antibody (Clone RM416) can be used for immunohistochemistry (IHC) and Western blot (WB) applications.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Weng, Y.-R., Cui, Y., and Fang, J.-Y. Biological functions of cytokeratin 18 in cancer. Mol. Cancer Res. 10(4), 485-493 (2012).

    2. Rabban, J.T., Soslow, R.A., and Zaloudek, C.Z. Immunohistology of the female genital tract. Diagnostic immunohistochemistry 690-762 (2010).

    3. Campbell, F., and Herrington, C.S. Application of cytokeratin 7 and 20 immunohistochemistry to diagnostic pathology. Curr. Diagn. Pathol. 7(2), 113-122 (2001).

    4. Mathers, M.E., Pollock, A.M., Marsh, C., et al. Cytokeratin 7: A useful adjunct in the diagnosis of chromophobe renal cell carcinoma. Histopathology 40(6), 563-567 (2002).

    5. Matsukuma, S., Takeo, H., Kono, T., et al. Aberrant cytokeratin 7 expression of centrilobular hepatocytes: A clinicopathological study. Histopathology 61(5), 857-862 (2012).