For immunochemical detection of H. pylori urease
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Urease Helicobacter pylori Rabbit Monoclonal Antibody (RM412)

Item No. 32343

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Immunogen
Proteins purified from H. pylori
Clone Designation
RM412
Formulation (Request formulation change)
100 µg of protein A-affinity purified monoclonal antibody
Storage Buffer
PBS with 50% glycerol, 1% BSA, and 0.09% sodium azide
Host
Rabbit
Isotype
IgG
Applications
ELISA
Cross Reactivity
(+) H. pylori urease
Species Reactivity
(+) H. pylori
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    100 µg

    $411

    Add
    Cayman Chemical
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    Product Description

    Helicobacter pylori (H. pylori) is a Gram-negative bacterium that can infect and colonize the stomach, leading to chronic gastritis, stomach inflammation and oxidative stress, peptic ulcer disease, and gastric cancer.1 H. pylori urease is a nickel-dependent enzyme that catalyzes the hydrolysis of urea to produce ammonia and bicarbonate, an effect that protects H. pylori by neutralizing stomach acid and contributes to the pathogenesis of H. pylori infection.2,3 It exists as a dodecamer of four αβ heterotrimers composed of UreB and UreA subunits, which contain the catalytic active sites and mediate subunit association, respectively.3,4 H. pylori urease is expressed predominantly in the cytoplasm but is also present on the cell surface.3 The activity of H. pylori urease has been used as a biomarker for H. pylori infection.5 Cayman's Urease Helicobacter pylori Rabbit Monoclonal Antibody (RM412) can be used for ELISA.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Chang, A.H., and Parsonnet, J. Role of bacteria in oncogenesis. Clin. Microbiol. Rev. 23(4), 837-857 (2010).

    2. Haley, K.P., and Gaddy, J.A. Metalloregulation of Helicobacter pylori physiology and pathogenesis. Front. Microbiol. 6, 911 (2015).

    3. Ha, N.-C., Oh, S.-T., Sung, J.Y., et al. Supramolecular assembly and acid resistance of Helicobacter pylori urease. Nat. Struct. Biol. 8(6), 505-509 (2001).

    4. Schoep, T.D., Fulurija, A., Good, F., et al. Surface properties of Helicobacter pylori urease complex are essential for persistence. PLoS One 5(11), e15042 (2010).

    5. Graham, D.Y., and Miftahussurur, M. Helicobacter pylori urease for diagnosis of Helicobacter pylori infection: A mini review. J. Adv. Res. 13, 51-57 (2018).