For immunochemical detection of γ heavy chain
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Alternative(s)
32107γ Heavy Chain (human) Monoclonal Antibody (Clone RM116)
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γ Heavy Chain (human) Rabbit Monoclonal Antibody - Biotinylated (RM116)

Item No. 32364

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Synonyms
  • IgG Heavy Chain
  • Immunoglobulin G Heavy Chain
Immunogen
Human IgG
Clone Designation
RM116
Formulation (Request formulation change)
50 µg of protein A-affinity purified monoclonal antibody
Storage Buffer
PBS with 50% glycerol, 1% BSA, and 0.09% sodium azide
Host
Rabbit
Isotype
IgG
Applications
ELISA, ICC, and IHC
Cross Reactivity
(+) IgG1(+) IgG2(+) IgG3(+) IgG4(-) Human IgM(-) Human IgA(-) Human IgD(-) Human IgE(-) Goat IgG(-) Mouse IgG(-) Rat IgG
Species Reactivity
(+) Human
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

    50 µg

    $411

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    Cayman Chemical
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    Product Description

    Immunoglobulin G (IgG) is a member of the immunoglobulin superfamily of glycoproteins that plays a central role in the adaptive immune response.1,2 It is produced by B cells and later secreted by plasma cells and is the most abundant circulating antibody in rabbit serum. IgG consists of two identical heavy chains, also known as γ heavy chains, of approximately 50 kDa each and two identical light chains of approximately 25 kDa each.1 The heavy chains are linked together by a single disulfide bond to form an Fc region and also combine with the light chains through additional disulfide bonds to form the Fab region, which mediate receptor and antigen binding, respectively. IgG is produced following IgM class-switching in response to infection and is involved in numerous humoral host defense responses, including antibody-dependent cell-mediated cytotoxicity (ADCC), toxin neutralization, and pathogen opsonization.1,3,4 γ Heavy chains are truncated and unable to associate with IgG light chains in patients with the rare disease γ heavy chain disease.5 Cayman's γ Heavy Chain (human) Rabbit Monoclonal Antibody - Biotinylated (RM116) can be used for ELISA and immunohistochemistry (IHC) applications. The antibody recognizes the Fc region of the γ heavy chain from human samples.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Weber, J., Peng, H., and Rader, C. From rabbit antibody repertoires to rabbit monoclonal antibodies. Exp. Mol. Med. 49(3), e305 (2017).

    2. Rayner, L.E., Kadkhodayi-Kholghi, N., Heenan, R.K., et al. The solution structure of rabbit IgG accounts for its interactions with the Fc receptor and complement C1q and its conformational stability. J. Mol. Biol. 425(3), 506-523 (2013).

    3. Vidarsson, G., Dekkers, G., and Rispens, T. IgG subclasses and allotypes: From structure to effector functions. Front. Immunol. 5, 520 (2014).

    4. Williams, R.C., Jr., Osterland, C.K., Margherita, S., et al. Studies of biologic and serologic activities of rabbit-IgG antibody depleted of carbohydrate residues. J. Immunol. 111(6), 1690-1698 (1973).

    5. Bieliauskas, S., Tubbs, R.R., Bacon, C.M., et al. Gamma heavy-chain disease: Defining the spectrum of associated lymphoproliferative disorders through analysis of 13 cases. Am. J. Surg. Pathol. 36(4), 534-543 (2012).