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N-desethyl Etonitazene

Item No. 32512

Restricted Product (Schedule I)
Product Insert (PDF)GC-MS (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-[(4-ethoxyphenyl)methyl]-N-ethyl-5-nitro-1H-benzimidazole-1-ethanamine
CAS Number
2732926-26-8
Molecular Formula
C20H24N4O3
Formula Weight
368.4
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 25 mg/mlDMF:PBS (pH 7.2) (1:1): 0.5 mg/mlDMSO: 20 mg/mlEthanol: 10 mg/ml
λmax
241 nm
SMILES
CCNCCN1C2=CC=C([N+]([O-])=O)C=C2N=C1CC3=CC=C(OCC)C=C3
InChi Code
InChI=1S/C20H24N4O3/c1-3-21-11-12-23-19-10-7-16(24(25)26)14-18(19)22-20(23)13-15-5-8-17(9-6-15)27-4-2/h5-10,14,21H,3-4,11-13H2,1-2H3
InChi Key
RESPFUMJVJRUMB-UHFFFAOYSA-N
Regulatory Information
DEA Schedule
I
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    Product Description

    N-desethyl Etonitazene (Item No. 32512) is an analytical reference standard categorized as an opioid.1,2 N-desethyl Etonitazene is a metabolite of etonitazene (Item No. 21824). This product is intended for research and forensic applications.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Krotulski, A.J., Papsun, D.M., Kacinko, S.L., et al. Isotonitazene quantitation and metabolite discovery in authentic forensic casework. J. Anal. Toxicol. 44(6), 521-530 (2020).

    2. Vandeputte, M.M., Van Uytfanghe, K., Layle, N.K., et al. Synthesis, chemical characterization, and µ-opioid receptor activity assessment of the emerging group of "nitazene" 2-benzylbenzimidazole synthetic opioids. ACS Chem. Neurosci. 12(7), 1241-1251 (2021).

    Product Citations

    Robinson, M.J., Chen, L., Thakur, A., et al. Coordinated subpocket engagement underlies nitazene potency at the μ‑opioid receptor. ACS Chem. Neurosci. (2026).

    Leonard, A.C., Lenert-Mondou, C., Chayer, R., et al. Computational design of dynamic biosensors for emerging synthetic opioids. BioRxiv (2025).

    Hardwick, E.K., and Davidson, J.T. Structural characterization of nitazene analogs using electrospray ionization-tandem mass spectrometry (ESI-MS/MS). Drug Test Anal. (2025).

    Kozell, L.B., Eshleman, A.J., Wolfrum, K.M., et al. Pharmacology of newly identified nitazene variants reveals structural determinants of affinity, potency, selectivity for mu opioid receptors. Neuropharmacology 276, 110512 (2025).

    Tsai, M.-H.M., Chen, L., Baumann, M.H., et al. In Vitro Functional Profiling of Fentanyl and Nitazene Analogs at the μ-Opioid Receptor Reveals High Efficacy for Gi Protein Signaling. ACS Chem. Neurosci. 15(4), 854-867 (2024).

    Monti, M.C., De Vrieze, L.M., Vandeputte, M.M., et al. Detection of N-desethyl etonitazene in a drug checking sample: Chemical analysis and pharmacological characterization of a recent member of the 2-benzylbenzimidazole "nitazene" class. J. Pharm. Biomed. Anal. 251:116453, (2024).

    Krotulski, A.J., Becker, K., Walton, S.E., et al. N-Desethyl Etonitazene — NPS Discovery New Drug Monograph. 1-4 (2023).

    Vandeputte, M.M., Van Uytfanghe, K., Layle, N.K., et al. Synthesis, chemical characterization, and µ-opioid receptor activity assessment of the emerging group of "nitazene" 2-benzylbenzimidazole synthetic opioids. ACS Chem. Neurosci. 12(7), 1241-1251 (2021).