A cGAS inhibitor
Technical Support & Resources

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

PF-06928215

Item No. 32515

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(1R,2S)-2-[[(7-hydroxy-5-phenylpyrazolo[1,5-a]pyrimidin-3-yl)carbonyl]amino]-cyclohexanecarboxylic acid
CAS Number
2378173-15-8
Molecular Formula
C20H20N4O4
Formula Weight
380.4
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMSO: 30 mg/ml
SMILES
OC([C@H](CCCC1)[C@H]1NC(C2=C3N(N=C2)C(O)=CC(C4=CC=CC=C4)=N3)=O)=O
InChi Code
InChI=1S/C20H20N4O4/c25-17-10-16(12-6-2-1-3-7-12)22-18-14(11-21-24(17)18)19(26)23-15-9-5-4-8-13(15)20(27)28/h1-3,6-7,10-11,13,15,25H,4-5,8-9H2,(H,23,26)(H,27,28)/t13-,15+/m1/s1
InChi Key
PHGTYMRDHDEHLI-HIFRSBDPSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    1 mg

    $95

    Add

    5 mg

    $439

    Add
    Cayman Chemical
    Neutrophil Biology Wall Poster

    Explore how neutrophils shape the immune response in health and disease. This poster highlights neutrophil pathogen defense mechanisms, including phagocytosis, degranulation, and NETosis, as well as neutrophil roles in inflammation and NET-associated pathologies.

    DOWNLOAD NOW
    Product Description

    PF-06928215 is an inhibitor of cyclic GMP-AMP synthase (cGAS; IC50 = 4.9 µM in a fluorescence polarization assay).1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Hall, J., Brault, A., Vincent, F., et al. Discovery of PF-06928215 as a high affinity inhibitor of cGAS enabled by novel fluorescence polarization assay. PLoS One 12(9), e0184843 (2017).