A STING agonist
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STING Agonist 12b

Item No. 32521

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-methoxy-5,6-dimethyl-9(10H)-acridinone
CAS Number
2411100-70-2
Synonyms
  • Stimulator of Interferon Genes Agonist 12b
Molecular Formula
C16H15NO2
Formula Weight
253.3
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 1 mg/mlDMSO: 1 mg/ml
λmax
271 nm
SMILES
O=C1C2=CC=C(C)C(C)=C2NC3=CC=C(C=C13)OC
InChi Code
InChI=1S/C16H15NO2/c1-9-4-6-12-15(10(9)2)17-14-7-5-11(19-3)8-13(14)16(12)18/h4-8H,1-3H3,(H,17,18)
InChi Key
SEVGTQHWWAYAQR-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    500 µg

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    1 mg

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    5 mg

    $392

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    10 mg

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    Cayman Chemical
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    Product Description

    STING agonist 12b is an agonist of stimulator of interferon genes (STING).1 It binds to STING (Kd = 26.4 µM) and induces interferon reporter gene expression in cells expressing human or mouse STING (EC50s = 7.45 and 10.23 µM, respectively). STING agonist 12b (40 µM) induces expression of TNF-a, IL-6, IP-10, and IL-1b in THP-1 cells.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Hou, S., Lan, X.-j., Li, W., et al. Design, synthesis and biological evaluation of acridone analogues as novel STING receptor agonists. Bioorg. Chem. 95, 103556 (2020).