An IL-4 inhibitor
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IL-4 Inhibitor

Item No. 32548

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-amino-4-(3,4-dihydroxyphenyl)-6-(4-fluorophenyl)-3-pyridinecarbonitrile
CAS Number
1332184-63-0
Molecular Formula
C18H12FN3O2
Formula Weight
321.3
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlDMSO:PBS (pH 7.2) (1:5): 0.1 mg/mlEthanol: 10 mg/ml
λmax
261, 355 nm
SMILES
N#CC1=C(N)N=C(C2=CC=C(F)C=C2)C=C1C3=CC(O)=C(O)C=C3
InChi Code
InChI=1S/C18H12FN3O2/c19-12-4-1-10(2-5-12)15-8-13(14(9-20)18(21)22-15)11-3-6-16(23)17(24)7-11/h1-8,23-24H,(H2,21,22)
InChi Key
DWZPPBGRCDPFSS-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    Cayman Chemical
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    Product Description

    IL-4 inhibitor is an inhibitor of IL-4.1 It binds to IL-4 with a Kd value of 1.8 μM and inhibits IL-4 activity in a cell-based reporter assay (EC50 = 1.81 μM). It is selective for IL-4 over IL-13 (EC50 = 18.2 μM). IL-4 inhibitor inhibits IL-4-induced STAT6 phosphorylation in THP-1 monocytes (EC50 = 3.1 μM), indicating inhibition of the IL-4-JAK1-STAT6 signaling pathway.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Quinnell, S.P., Leifer, B.S., Nestor, S.T., et al. A small-molecule inhibitor to the cytokine interleukin-4. ACS Chem. Biol. 15(10), 2649-2654 (2020).