For immunochemical detection of MR1
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Alternative(s)
34257MR1 Monoclonal Antibody (Clone 2H7)
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MR1 Monoclonal Antibody (Clone 26.5)

Item No. 32549

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Synonyms
  • Class I Histocompatibility Antigen-like Protein
  • Major Histocompatibility Complex Class I-related Gene Protein
  • MHC Class I-related Gene Protein
Immunogen
Recombinant fragment containing 280 amino acids from the extracellular domain of human MR1
Clone Designation
26.5
Formulation (Request formulation change)
100 µg of protein G-affinity purified monoclonal antibody
Storage Buffer
PBS, pH 7.2, with 50% glycerol and 0.02% sodium azide
Host
Mouse
Isotype
IgG2a
Applications
FC, IP (mass spec confirmed), WB
Cross Reactivity
(+) MR1
Species Reactivity
(+) Human(+) bovine(+) mouse(+) rat
UniProt Accession №
Q95460
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    100 µg

    $347

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    Cayman Chemical
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    Product Description

    Major histocompatibility complex class I-related gene protein (MR1) is a non-polymorphic MHC class Ib antigen-presenting cell surface molecule that is required for T cell receptor-mediated activation of mucosal-associated invariant T (MAIT) cells.1,2 It is composed of α1 and α2 domains, which form an antigen-binding pocket, and an α3 domain that interacts with β2-microglobulin.2 MR1 mRNA is ubiquitously expressed and, following translation, MR1 protein is localized to the endoplasmic reticulum in a partially folded state. Upon binding of a riboflavin-derived microbial antigen, MR1 undergoes a conformational change and translocates to the cell surface where it induces MAIT cell activation via an interaction with the MAIT cell T cell receptor and activates various immunomodulatory effects, including cytokine release, initiation of adaptive immune responses, and promotion of tissue repair.3 Cayman’s MR1 Monoclonal Antibody (Clone 26.5) can be used for flow cytometry (FC), immunoprecipitation (mass spec confirmed) (IP), and Western blot (WB) applications. The antibody recognizes MR1 from human, bovine, mouse, and rat samples.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Lamichhane, R., and Ussher, J.E. Expression and trafficking of MR1. Immunology 151(3), 270-279 (2017).

    2. Krovi, S.H., and Gapin, L. Structure and function of the non-classical major histocompatibility complex molecule MR1. Immunogenetics 68(8), 549-559 (2016).

    3. McWilliam, H.E.G., and Salio, M. Understanding and modulating the MR1 metabolite antigen presentation pathway. Mol. Immunol. 129, 121-126 (2021).