An inhibitor of ABCG2
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ML-230

Item No. 32552

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3-furanyl[4-[5-(2-furanyl)-2-phenylpyrazolo[1,5-a]pyrimidin-7-yl]-1-piperazinyl]-methanone
CAS Number
1776055-05-0
Synonyms
  • CID-44640177
Molecular Formula
C25H21N5O3
Formula Weight
439.5
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
λmax
285, 296 nm
SMILES
O=C(N1CCN(CC1)C2=CC(C3=CC=CO3)=NC4=CC(C5=CC=CC=C5)=NN42)C6=COC=C6
InChi Code
InChI=1S/C25H21N5O3/c31-25(19-8-14-32-17-19)29-11-9-28(10-12-29)24-16-21(22-7-4-13-33-22)26-23-15-20(27-30(23)24)18-5-2-1-3-6-18/h1-8,13-17H,9-12H2
InChi Key
LRPGMVPQQLBMNE-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $90

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    5 mg

    $392

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    10 mg

    $696

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    Cayman Chemical
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    Product Description

    ML-230 is an inhibitor of ATP-binding cassette family G member 2 (ABCG2).1 It selectively inhibits JC-1 efflux in Ig-MXP3 cells overexpressing ABCG2 over Jurkat cells overexpressing ABCB1 (IC50s = 0.13 and 4.65 µM, respectively). ML-230 enhances inhibition of IGROV-1/T8 ovarian cancer cell colony formation induced by topotecan (Item No. 14129).2 Intratumoral injection of ML-230 (100 nM) and topotecan reduces tumor size in an IGROV-1/T8 mouse xenograft model.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Strouse, J.J., Ivnitski-Steele, I., Khawaja, H.M., et al. A selective ATP-binding cassette subfamily G member 2 efflux inhibitor revealed via high-throughput flow cytometry. J. Biomol. Screen. 18(1), 26-38 (2013).

    2. Ricci, J.W., Lovato, D.M., Severns, V., et al. Novel ABCG2 antagonists reverse topotecan-mediated chemotherapeutic resistance in ovarian carcinoma xenografts. Mol. Cancer Ther. 15(12), 2853-2862 (2016).