Active • Host: HEK293 cells • AA: 1-322 (full length) • Tag: C-terminal His • MW: 36 kDa
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ARG1 (human, recombinant)

Item No. 32558

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Synonyms
  • Arginase1
  • Liver-type Arginase
  • Type I Arginase
Purity
≥90% as determined by SDS-PAGE
Source
Active recombinant human C-terminal His-tagged ARG1 expressed in HEK293 cells
Amino Acids
1-322 (full length)
MW
36 kDa
Formulation (Request formulation change)
8 mM Phosphate buffer, pH 7.4, with 110 mM sodium chloride, 2.2 mM potassium chloride, and 20% glycerol
UniProt Accession №
P05089
Shipping & Storage Information
Storage
-80°C
Shipping
Dry ice in continental US; may vary elsewhere
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    50 µg

    $600

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    Cayman Chemical
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    Product Description

    Arginase-1 (ARG1) is a manganese-metalloenzyme that catalyzes the irreversible hydrolysis of L-arginine into urea and L-ornithine with roles in polyamine synthesis and tissue repair.1,2,3 It functions as a homotrimer with each subunit containing a binuclear manganese cluster at its active site.2 ARG1 is expressed primarily in the liver, and at lower levels in various extrahepatic tissues, including the heart, lung, intestine, and stomach, as well as the CNS, blood vessels, and M2 macrophages.1 Loss-of-function mutations in ARG1 are associated with the autosomal recessive disorder arginase-1 deficiency that is characterized by neurological impairment, growth retardation, spastic paraparesis, and hyperargininemia.2 ARG1 expression is increased in lung homogenates isolated from patients with asthma.4 Cayman’s ARG1 (human, recombinant) protein can be used for enzyme assay applications.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Moretto, J., Girard, C., and Demougeot, C. The role of arginase in aging: A systematic review. Exp. Gerontol. 116, 54-73 (2019).

    2. Sin, Y.Y., Baron, G., Schulze, A., et al. Arginase-1 deficiency. J. Mol. Med. (Berl.) 93(12), 1287-1296 (2015).

    3. Greenhalgh, A.D., Passos Dos Santos, R., Zarruk, J.G., et al. Arginase-1 is expressed exclusively by infiltrating myeloid cells in CNS injury and disease. Brain Behav. Immun. 56, 61-67 (2016).

    4. North, M.L., Khanna, N., Marsden, P.A., et al. Functionally important role for arginase 1 in the airway hyperresponsiveness of asthma. Am. J. Physiol. Lung Cell Mol. Physiol. 296(6), L911-L920 (2009).