A purine nucleotide
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2'-Deoxyadenosine-5'-O-triphosphate (sodium salt hydrate)

Item No. 32566

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
((2R,3S,5R)-5-(6-amino-9H-purin-9-yl)-3-hydroxytetrahydrofuran-2-yl)methyl hydrogen triphosphate, trisodium salt, hydrate
Synonyms
  • dATP
Molecular Formula
C10H13N5O12P3 • 3Na [XH2O]
Formula Weight
557.1
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
PBS (pH 7.2): 10 mg/ml
λmax
259 nm
SMILES
NC1=NC=NC2=C1N=CN2[C@@]3([H])C[C@H](O)[C@@H](COP(OP(OP(O)([O-])=O)([O-])=O)([O-])=O)O3.[Na+].[Na+].[Na+].O
InChi Code
InChI=1S/C10H16N5O12P3.3Na.H2O/c11-9-8-10(13-3-12-9)15(4-14-8)7-1-5(16)6(25-7)2-24-29(20,21)27-30(22,23)26-28(17,18)19;;;;/h3-7,16H,1-2H2,(H,20,21)(H,22,23)(H2,11,12,13)(H2,17,18,19);;;;1H2/q;3*+1;/p-3/t5-,6+,7+;;;;/m0..../s1
InChi Key
RQGMMLFBAUODIH-YYWCTZDQSA-K
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    25 mg

    $75

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    50 mg

    $134

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    100 mg

    $252

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    250 mg

    $516

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    Product Description

    2'-Deoxyadenosine-5'-O-triphosphate (dATP) is a purine nucleotide and derivative of the nucleic acid adenosine 5’-triphosphate (Item No. 14498).1 dATP is a substrate for DNA polymerase in the synthesis of DNA.2 It is a noncompetitive inhibitor of ribonucleotide reductases, which provides feedback inhibition during DNA synthesis.1 dATP has commonly been used in DNA synthesis, sequencing, and labeling in research applications.3,4 dATP accumulates in adenosine deaminase deficiency, a disorder characterized by mutations in the gene for adenosine deaminase, the enzyme that catalyzes the deamination of adenosine and deoxyadenosine.5

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Berg, J.M., Tymoczko, J.L., and Stryer, L. Key steps in nucleotide biosynthesis are regulated by feedback inhibition. Biochemistry (2002).

    2. Berg, J.M., Tymoczko, J.L., and Stryer, L. DNA is replicated by polymerases that take instructions from templates. Biochemistry (2002).

    3. Cadwell, R.C., and Joyce, G.F. Randomization of genes by PCR mutagenesis. PCR Methods Appl. 2(1), 28-33 (1992).

    4. Steffens, D.L., Jang, G.Y., Sutter, S.L., et al. An infrared fluorescent dATP for labeling DNA. Genome Res. 5(4), 393-399 (1995).

    5. Flinn, A.M., and Gennery, A.R. Adenosine deaminase deficiency: A review. Orphanet J. Rare Dis. 13(1), 65 (2018).